ArticleClinical & experimental metastasis1998
Expression of gelatinases A and B, stromelysin-3 and matrilysin genes in breast carcinomas: clinico-pathological correlations.
Article in Clinical & experimental metastasis, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- Expression of Matrix Metalloproteinase-7 Predicts Poor Prognosis in Gastric Cancer.BioMed research international · 2022Article
- Matrix Metalloprotease-7 Mediates Nucleolar Assembly and Intra-nucleolar Cleaving p53 in Gefitinib-Resistant Cancer Stem Cells.iScience · 2020Article
- In Vivo Biosensing Using Resonance Energy Transfer.Biosensors · 2019Review
- A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1.Biomolecules & therapeutics · 2015Article
- Plasma matrix metalloproteinase 2 levels and breast cancer risk.Cancer epidemiology · 2015Article
- Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases.The Journal of pathology · 2015Article
- The regulation of MMP targeting to invadopodia during cancer metastasis.Frontiers in cell and developmental biology · 2015Review
- Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo.Bioorganic & medicinal chemistry letters · 2014Article
- Evaluation of a triple-helical peptide with quenched FluorSophores for optical imaging of MMP-2 and MMP-9 proteolytic activity.Molecules (Basel, Switzerland) · 2014Article
- Article
- Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe.Bioconjugate chemistry · 2012Article
- Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer.Cancer research · 2010Article
- Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: New findings and review of the literature.BMC cancer · 2009Article
- Genetic polymorphisms in the MMP-7 gene and breast cancer survival.International journal of cancer · 2009Article
- Role of siRNA silencing of MMP-2 gene on invasion and growth of laryngeal squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2008Article
- Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality.Cancer research · 2008Article
- Clinical significance of serum MMP-2 and MMP-7 in patients with ovarian cancer.Medical oncology (Northwood, London, England) · 2008Article
- Nanoparticle self-assembly gated by logical proteolytic triggers.Journal of the American Chemical Society · 2007Article
- Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression.BMC cancer · 2006Article
- Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast.Yonsei medical journal · 2006Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the association among matrix metalloproteinases (gelatinases A and B, stromelysin-3 (ST3) and matrilysin) mRNAs expressed in primary breast carcinomas and standard prognostic parameters and clinical outcome. mRNA levels were determined by Northern analysis in samples of 81 breast cancer patients (median follow-up, 40 months) and 27 samples of uninvolved adjacent breast tissue. Proteases were expressed by the majority of the tumors and normal breast tissues examined. ST3, gelatinase A and matrilysin mRNAs were more often expressed at high levels in carcinomatous than in normal breast tissues. Differences in the distribution of gelatinase B mRNA were not found. However, paired normal tissues generally produced weaker signals when compared to matched tumor samples. Univariate analysis showed no significant association of gelatinase A and matrilysin mRNAs with the classical prognostic markers (age, menopausal status, stage, size, nodal status, vascular infiltrate, necrosis, steroid receptors, metastasis and survival). Overexpression of ST3 was more frequently found in tumors of post-menopausal women (P < 0.022). Elevated expression of gel B mRNA was associated with the presence of vascular infiltrate (P < 0.026), necrosis (P < 0.039), PR negative tumors (P < 0.014) and inversely correlated to the number of survivors (P < 0.021). Multivariate analysis including 68 patients for whom all information was available indicated that neither stromelysin correlated significantly with pathological, clinical or biochemical features. High levels of gelatinase A and B mRNAs were inversely associated with the number of survivors. Our findings suggest that measurements of gelatinase A and B mRNAs expression in breast carcinoma may help to identify patients with an aggressive form of the disease.
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