ArticleJournal of clinical pathology1998
The limited difference between keratin patterns of squamous cell carcinomas and adenocarcinomas is explicable by both cell lineage and state of differentiation of tumour cells.
Article in Journal of clinical pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- SPIN-AI: A Deep Learning Model That Identifies Spatially Predictive Genes.Biomolecules · 2023Article
- Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation.Oncogene · 2019Article
- Rare pancreatic carcinosarcoma in a patient with medical history of esophageal cancer: A case report and literature review.Medicine · 2019Review
- Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft.Transplantation · 2018Article
- Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.Cancer research · 2017Article
- p120-catenin down-regulation and epidermal growth factor receptor overexpression results in a transformed epithelium that mimics esophageal squamous cell carcinoma.The American journal of pathology · 2015Article
- SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma.Molecular cancer · 2014Article
- Immunohistochemical features of the gastrointestinal tract tumors.Journal of gastrointestinal oncology · 2012Article
- A case of carcinoma of the male breast mimicking a mucinous carcinoma of the skin.Clinics and practice · 2012Article
- Induction of human squamous cell-type carcinomas by arsenic.Journal of skin cancer · 2011Article
- Diagnosis and treatment of a neck node swelling suspicious for a malignancy: an algorithmic approach.International journal of surgical oncology · 2010Article
- Article
- Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion.Journal of clinical pathology · 2007Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the differentiation of epithelial tissues within their histological context, and to identify hypothetically, on the basis of keratin pattern, the putative tissue origin of a (metastatic) carcinoma.
methodsUsing well characterised monoclonal antibodies against individual keratins 7, 8, 18, and 19, which are predominantly found in columnar epithelia, and keratins 4, 10, 13, and 14, predominantly expressed in (non)-keratinising squamous epithelia, the keratin patterns for a series of 45 squamous cell carcinomas and 44 adenocarcinomas originating from various epithelial tissues were characterised.
resultsThe predominant keratins in all adenocarcinomas proved to be 8, 18, and 19. In addition, these keratins were also abundantly present in squamous cell carcinomas of the lung, cervix, and rectum and, to a lesser extent, of the larynx, oesophagus, and tongue, but not in those of the vulva and skin. Keratins 4, 10, 13, and 14 were present in almost all squamous cell carcinomas, but also focally in some of the adenocarcinomas studied.
conclusionsThere is a limited differential expression of distinctive keratin filaments between squamous cell carcinomas and adenocarcinomas. Apparently, squamous cell carcinomas that originate from columnar epithelium by squamous metaplasia gain the keratins of squamous cells but retain the keratins of columnar epithelial cells. However, the simultaneous expression of two of three squamous keratins (4, 10, and 13) identifies a squamous cell carcinoma, and thus might be useful in solving differential diagnostic problems.
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