ArticleBiophysical journal1999
Kramers' diffusion theory applied to gating kinetics of voltage-dependent ion channels.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Beta-Barrel Channel Response to High Electric Fields: Functional Gating or Reversible Denaturation?International journal of molecular sciences · 2023Article
- Fifty years of gating currents and channel gating.The Journal of general physiology · 2023Review
- Gating current noise produced by Brownian models of a voltage sensor.Biophysical journal · 2021Article
- Microcanonical coarse-graining of the kinetic Ising model.The Journal of chemical physics · 2020Article
- Gating currents.The Journal of general physiology · 2018Review
- Heat pulse excitability of vestibular hair cells and afferent neurons.Journal of neurophysiology · 2016Article
- Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors.The journal of physical chemistry. B · 2015Article
- Modeling ion channels: past, present, and future.The Journal of general physiology · 2014Review
- Coarse-grained simulations of the gating current in the voltage-activated Kv1.2 channel.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Wavelet-based protocols for ion channel electrophysiology.BMC biophysics · 2013Article
- Gating of maxi channels observed from pseudo-phase portraits.American journal of physiology. Cell physiology · 2013Article
- A linkage analysis toolkit for studying allosteric networks in ion channels.The Journal of general physiology · 2013Article
- Multi-scale electrophysiology modeling: from atom to organ.The Journal of general physiology · 2010Article
- An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels.The Journal of biological chemistry · 2010Article
- A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Using stochastic models calibrated from nanosecond nonequilibrium simulations to approximate mesoscale information.The Journal of chemical physics · 2009Article
- Quantifying multiscale noise sources in single-molecule time series.The journal of physical chemistry. B · 2009Article
- Extracting Kinetic and Stationary Distribution Information from Short MD Trajectories via a Collection of Surrogate Diffusion Models.Journal of chemical theory and computation · 2009Article
- Multiscale modeling of cardiac cellular energetics.Annals of the New York Academy of Sciences · 2005Review
- A speed limit for conformational change of an allosteric membrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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3 authors.
Funding
Abstract
Kramers' diffusion theory of reaction rates in the condensed phase is considered as an alternative to the traditional discrete-state Markov (DSM) model in describing ion channel gating current kinetics. Diffusion theory can be expected to be particularly relevant in describing high-frequency (>100 kHz) events in channel activation. The generalized voltage sensor of a voltage-dependent ion channel is treated as a Brownian motion particle undergoing spatial diffusion along a one-dimensional energy landscape. Two classes of energy landscapes are considered. The first class contains large barriers, which give rise to gating currents with two distinct time scales: the usual low-frequency decay, which can modeled with a DSM scheme, and a high-frequency component arising from intrastate relaxation. Large depolarizations reduce potential barriers to such a degree that activation rates are diffusion limited, causing the two time scales to merge. Landscapes of the second class are either featureless or contain barriers that are small compared to kT; these are termed "drift landscapes." These landscapes require a larger friction coefficient to generate slow gating kinetics. The high-frequency component that appears with barrier models is not present in pure drift motion. The presence of a high-frequency component can be tested experimentally with large-bandwidth recordings of gating currents. Topics such as frequency domain analysis, spatial dependence of the friction coefficient, methods for determining the adequacy of a DSM model, and the development of physical models of gating are explored.
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