ArticleBiophysical journal1999
Modeling study of the effects of overlapping Ca2+ microdomains on neurotransmitter release.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 106 citations in OpenAlex.
- Physiology of intracellular calcium buffering.Physiological reviews · 2023Review
- Stationary CaBiophysical journal · 2021Article
- Efficient Approximations for Stationary Single-Channel CaBiophysical journal · 2020Article
- Extension of Rapid Buffering Approximation to CaBiophysical journal · 2018Article
- Padé Approximation of a Stationary Single-Channel CaBiophysical journal · 2016Article
- Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling.Channels (Austin, Tex.) · 2015Article
- Nanodomain coupling between Ca²⁺ channels and sensors of exocytosis at fast mammalian synapses.Nature reviews. Neuroscience · 2011Review
- Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap.Brain research · 2011Review
- Nanodomain control of exocytosis is responsible for the signaling capability of a retinal ribbon synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse.Nature neuroscience · 2010Article
- Ca2+ current versus Ca2+ channel cooperativity of exocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Modeling study of the effects of membrane surface charge on calcium microdomains and neurotransmitter release.Biophysical journal · 2008Article
- Ca2+ from one or two channels controls fusion of a single vesicle at the frog neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Influence of Ca2+-binding proteins and the cytoskeleton on Ca2+-dependent inactivation of high-voltage activated Ca2+ currents in thalamocortical relay neurons.Pflugers Archiv : European journal of physiology · 2005Article
- Buffers and oscillations in intracellular Ca2+ dynamics.Biophysical journal · 2003Article
- Three-dimensional reconstruction of a calyx of Held and its postsynaptic principal neuron in the medial nucleus of the trapezoid body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Stochastic properties of Ca(2+) release of inositol 1,4,5-trisphosphate receptor clusters.Biophysical journal · 2002Article
- Calcium secretion coupling at calyx of Held governed by nonuniform channel-vesicle topography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Presynaptic Ca2+ channels and neurotransmitter release at the terminal of a mouse cortical neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Quantitative relationship between transmitter release and calcium current at the calyx of held synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although single-channel Ca2+ microdomains are capable of gating neurotransmitter release in some instances, it is likely that in many cases the microdomains from several open channels overlap to activate vesicle fusion. We describe a mathematical model in which transmitter release is gated by single or overlapping Ca2+ microdomains produced by the opening of nearby Ca2+ channels. This model accounts for the presence of a mobile Ca2+ buffer, provided either that the buffer is unsaturable or that it is saturated near an open channel with Ca2+ binding kinetics that are rapid relative to Ca2+ diffusion. We show that the release time course is unaffected by the location of the channels (at least for distances up to 50 nm), but paired-pulse facilitation is greater when the channels are farther from the release sites. We then develop formulas relating the fractional release following selective or random channel blockage to the cooperative relationship between release and the presynaptic Ca2+ current. These formulas are used with the transmitter release model to study the dependence of this form of cooperativity, which we call Ca2+ current cooperativity, on mobile buffers and on the local geometry of Ca2+ channels. We find that Ca2+ current cooperativity increases with the number of channels per release site, but is considerably less than the number of channels, the theoretical upper bound. In the presence of a saturating mobile buffer the Ca2+ current cooperativity is greater, and it increases more rapidly with the number of channels. Finally, Ca2+ current cooperativity is an increasing function of channel distance, particularly in the presence of saturating mobile buffer.
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