ArticleBiophysical journal1999
Modeling chemotactic cell sorting during Dictyostelium discoideum mound formation.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Physical Mechanisms Driving Cell Sorting in Hydra.Biophysical journal · 2017Article
- Dislocation is a developmental mechanism in Dictyostelium and vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dictyostelium: The Mathematician's Organism.Current genomics · 2013Article
- Dictyostelium discoideum SecG interprets cAMP-mediated chemotactic signals to influence actin organization.Cytoskeleton (Hoboken, N.J.) · 2013Article
- Loss of the histidine kinase DhkD results in mobile mounds during development of Dictyostelium discoideum.PloS one · 2013Article
- Regulation of multiple tip formation by caffeine in cellular slime molds.BMC developmental biology · 2012Article
- Phospholipase D controls Dictyostelium development by regulating G protein signaling.Cellular signalling · 2011Article
- Cell-oriented modeling of angiogenesis.TheScientificWorldJournal · 2011Review
- Coordination of cell differentiation and migration in mathematical models of caudal embryonic axis extension.PloS one · 2011Article
- Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.Cold Spring Harbor perspectives in biology · 2009Review
- Article
- Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the "inside and outside" pattern of cell sorting.BMC systems biology · 2007Article
- Cell elongation is key to in silico replication of in vitro vasculogenesis and subsequent remodeling.Developmental biology · 2006Article
- Becoming Multicellular by Aggregation; The Morphogenesis of the Social Amoebae Dicyostelium discoideum.Journal of biological physics · 2002Article
- The control of chemotactic cell movement during Dictyostelium morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coordinated cell movement is a major mechanism of the multicellular development of most organisms. The multicellular morphogenesis of the slime mould Dictyostelium discoideum, from single cells into a multicellular fruiting body, results from differential chemotactic cell movement. During aggregation cells differentiate into prestalk and prespore cells that will form the stalk and spores in the fruiting body. These cell types arise in a salt and pepper pattern after what the prestalk cells chemotactically sort out to form a tip. The tip functions as an organizer because it directs the further development. It has been difficult to get a satisfactory formal description of the movement behavior of cells in tissues. Based on our experiments, we consider the aggregate as a drop of a viscous fluid and show that this consideration is very well suited to mathematically describe the motion of cells in the tissue. We show that the transformation of a hemispherical mound into an elongated slug can result from the coordinated chemotactic cell movement in response to scroll waves of the chemoattractant cAMP. The model calculations furthermore show that cell sorting can result from differences in chemotactic cell movement and cAMP relay kinetics between the two cell types. During this process, the faster moving and stronger signaling cells collect on the top of the mound to form a tip. The mound then extends into an elongated slug just as observed in experiments. The model is able to describe cell movement patterns in the complex multicellular morphogenesis of Dictyostelium rather well and we expect that this approach may be useful in the modeling of tissue transformations in other systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.