ArticleAnnals of the New York Academy of Sciences1998
The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells: evidence by immunocytochemistry and RT-PCR.
Article in Annals of the New York Academy of Sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Impact of autoimmune gastritis on chronic urticaria in paediatric patients - pathophysiological point of views.European journal of pediatrics · 2024Review
- Signal Transduction by VIP and PACAP Receptors.Biomedicines · 2022Review
- PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells.International journal of molecular sciences · 2021Article
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Physiological and Pathological Processes within the Gastrointestinal Tract: A Review.International journal of molecular sciences · 2021Review
- Diabetes Affects the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Like Immunoreactive Enteric Neurons in the Porcine Digestive Tract.International journal of molecular sciences · 2021Article
- PACAP38 and PACThe journal of headache and pain · 2018Review
- Presence and Effects of Pituitary Adenylate Cyclase Activating Polypeptide Under Physiological and Pathological Conditions in the Stomach.Frontiers in endocrinology · 2018Review
- Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan.Scientific reports · 2017Article
- VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies.Current opinion in endocrinology, diabetes, and obesity · 2011Review
- PAC1 deficiency in a murine model induces gastric mucosa hypertrophy and higher basal gastric acid output.Journal of molecular neuroscience : MN · 2011Article
- Ghrelin and gastric acid secretion.World journal of gastroenterology · 2008Review
- Tachyphylaxis of the ECL-cell response to PACAP: receptor desensitization and/or depletion of secretory products.British journal of pharmacology · 2007Article
- Histamine mediates the stimulatory action of ghrelin on acid secretion in rat stomach.Digestive diseases and sciences · 2006Article
- The vagus regulates histamine mobilization from rat stomach ECL cells by controlling their sensitivity to gastrin.The Journal of physiology · 2005Article
- Genetic dissection of the signaling pathways that control gastric acid secretion.Inflammopharmacology · 2005Review
- Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons.Regulatory peptides · 2002Article
- Gastrin and the neuropeptide PACAP evoke secretion from rat stomach histamine-containing (ECL) cells by stimulating influx of Ca2+ through different Ca2+ channels.The Journal of physiology · 2001Article
- Article
- Role of PACAP1 receptor in regulation of ECL cells and gastric acid secretion by pituitary adenylate cyclase activating peptide.Annals of the New York Academy of Sciences · 2000Article
- The effect of Zollinger-Ellison syndrome and neuropeptide-secreting tumors on the stomach.Current gastroenterology reports · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The current study was undertaken to determine the presence and distribution of PAC1-Rs within the gastric mucosa. Polyclonal antibodies to the carboxyl terminus of the rat PAC1-R were generated and shown to be specific against the PAC1-R expressed in NIH 3T3 cells. Western blot analysis using isolated (approximately 85% pure) ECL cell membranes identified a 48 kD protein consistent with the calculated molecular mass of the cloned PAC1-R. RT/PCR performed using specific primers for the PAC1-R confirmed the presence of splice variants of the rat PAC1-R, but not VPAC1-R or VPAC2-R. These data provide the first direct evidence for the existence of functional PACAP Type I receptors on ECL cells of the gastric mucosa and suggest a potential role for PACAP in the stimulation of gastric acid secretion and in the regulation of the growth of ECL cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.