ArticleProceedings of the National Academy of Sciences of the United States of America1999
Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 181 citations in OpenAlex.
- Review
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- Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex.Biochemical and biophysical research communications · 2018Article
- Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells.Odontology · 2018Article
- Article
- Pathogenesis and management of adenoviral keratoconjunctivitis.Infection and drug resistance · 2018Review
- Incontinentia pigmenti with secondary Raynaud's phenomenon: A case report and review of the literature.American journal of ophthalmology case reports · 2017Article
- Inducible turnover of optineurin regulates T cell activation.Molecular immunology · 2017Article
- NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.Cell death & disease · 2016Article
- Quantification of cellular NEMO content and its impact on NF-κB activation by genotoxic stress.PloS one · 2015Article
- A method for the quantitative analysis of stimulation-induced nuclear translocation of the p65 subunit of NF-κB from patient-derived dermal fibroblasts.Methods in molecular biology (Clifton, N.J.) · 2015Article
- STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus.Journal of virology · 2014Article
- Adenovirus E3 protein modulates leukocyte functions.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- NF-κB, the first quarter-century: remarkable progress and outstanding questions.Genes & development · 2012Review
- Gene Expression Analysis of Toll-Like Receptor Pathways in Heterophils from Genetic Chicken Lines that Differ in Their Susceptibility to Salmonella enteritidis.Frontiers in genetics · 2012Article
- RIP1-mediated regulation of lymphocyte survival and death responses.Immunologic research · 2011Review
- The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling.Journal of virology · 2011Article
- The zinc finger domain of IKKγ (NEMO) protein in health and disease.Journal of cellular and molecular medicine · 2010Review
- NF-κB inducing kinase: a key regulator in the immune system and in cancer.Cytokine & growth factor reviews · 2010Review
- NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling.Cell death and differentiation · 2009Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
FIP-3 (14.7K interacting protein) was discovered during a search for cell proteins that could interact with an adenovirus protein (Ad E3-14.7K) that had been shown to prevent tumor necrosis factor (TNF)-alpha-induced cytolysis. FIP-3, which contains leucine zippers and a zinc finger domain, inhibits both basal and induced transcriptional activity of NF-kappaB and causes a late-appearing apoptosis with unique morphologic manifestations. Ad E3-14.7K can partially reverse apoptotic death induced by FIP-3. FIP-3 also was shown to bind to other cell proteins, RIP and NIK, which previously had been described as essential components of TNF-alpha-induced NF-kappaB activation. In addition, FIP-3 inhibited activation of NF-kappaB induced by TNF-alpha, the TNFR-1 receptor, RIP, NIK, and IKKbeta, as well as basal levels of endogenous NF-kappaB in 293 cells. Because the activation of NF-kappaB has been shown to inhibit apoptosis, FIP-3 appears both to activate a cell-death pathway and to inhibit an NF-kappaB-dependent survival mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.