ArticleProceedings of the National Academy of Sciences of the United States of America1999
Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 107 citations in OpenAlex.
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- Misregulation of ELK1, AP1, and E12 Transcription Factor Networks Is Associated with Melanoma Progression.Cancers · 2020Article
- E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway.Journal of experimental & clinical cancer research : CR · 2019Article
- Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells.Frontiers of medicine · 2018Review
- New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Frontiers in biology · 2016Article
- Basic helix loop helix (bHLH) transcription factor 3 (TCF3, E2A) is regulated by androgens in prostate cancer cells.American journal of cancer research · 2015Article
- Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias.Leukemia research · 2015Article
- Article
- Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways.Nucleic acids research · 2014Article
- E proteins in lymphocyte development and lymphoid diseases.Current topics in developmental biology · 2014Review
- E2A predicts prognosis of colorectal cancer patients and regulates cancer cell growth by targeting miR-320a.PloS one · 2014Article
- E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells.Journal of translational medicine · 2013Article
- The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells.Blood · 2012Article
- Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.Biochemical and biophysical research communications · 2012Article
- HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.Clinical & developmental immunology · 2012Review
- E proteins and the regulation of early lymphocyte development.Immunological reviews · 2010Review
- Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection.The Journal of experimental medicine · 2010Article
- Transcriptional regulation of NKT cell development and homeostasis.Current opinion in immunology · 2010Review
- Transcriptional regulator Id2 controls survival of hepatic NKT cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A tamoxifen inducible knock-in allele for investigation of E2A function.BMC developmental biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice with null mutations in the E2A gene are highly susceptible to the spontaneous development of thymic lymphomas. To understand better how E2A deficiency may contribute to lymphomagenesis, we have observed the consequences of enforced expression of the E2A gene products E12 and E47 in cell lines derived from lymphomas that arose spontaneously in E2A-deficient mice. E2A-expressing cells are steadily eliminated from lymphoma cultures into which E47 or E12 was introduced. The mechanism underlying the loss of E2A-expressing cells does not involve an arrest in cell-cycle progression. Rather, the E2A proteins activate a programmed cell death pathway in these lymphomas. This E2A-mediated cell death appears to be preceded by a loss of mitochondrial transmembrane potential. These data provide direct evidence that E2A gene products can act as tumor suppressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.