ArticleProceedings of the National Academy of Sciences of the United States of America1999
Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 133 citations in OpenAlex.
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- The C. elegans eggshell.WormBook : the online review of C. elegans biology · 2018Review
- Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.PLoS genetics · 2017Article
- High-Throughput Cloning of Temperature-Sensitive Caenorhabditis elegans Mutants with Adult Syncytial Germline Membrane Architecture Defects.G3 (Bethesda, Md.) · 2015Article
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- Structure-based evolutionary relationship of glycosyltransferases: a case study of vertebrate β1,4-galactosyltransferase, invertebrate β1,4-N-acetylgalactosaminyltransferase and α-polypeptidyl-N-acetylgalactosaminyltransferase.Current opinion in structural biology · 2010Review
- Phylogenetic conservation of the cell-type-specific Lan3-2 glycoepitope in Caenorhabditis elegans.Development genes and evolution · 2010Article
- The role of nucleotide sugar transporters in development of eukaryotes.Seminars in cell & developmental biology · 2010Review
- A monoclonal antibody toolkit for C. elegans.PloS one · 2010Article
- Systematic analysis of dynamic miRNA-target interactions during C. elegans development.Development (Cambridge, England) · 2009Article
- APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.Molecular biology of the cell · 2008Article
- XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity.The Journal of biological chemistry · 2007Article
- lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.Developmental biology · 2007Article
- Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates.Journal of molecular biology · 2007Article
- Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans.Molecular biology of the cell · 2006Article
- Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
We have molecularly analyzed three genes, sqv-3, sqv-7, and sqv-8, that are required for wild-type vulval invagination in Caenorhabditis elegans. The predicted SQV-8 protein is similar in sequence to two mammalian beta(1,3)-glucuronyltransferases, one of which adds glucuronic acid to protein-linked galactose-beta(1, 4)-N-acetylglucosamine. SQV-3 is similar to a family of glycosyltransferases that includes vertebrate beta(1, 4)-galactosyltransferases, which create galactose-beta(1, 4)-N-acetylglucosamine linkages. One model is therefore that SQV-8 uses a SQV-3 product as a substrate. SQV-7 is similar to members of a family of nucleotide-sugar transporters. The sqv genes therefore are likely to encode components of a conserved glycosylation pathway that assembles a C. elegans carbohydrate moiety, the absence of which perturbs vulval invagination.
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