ArticleProceedings of the National Academy of Sciences of the United States of America1999
U1 small nuclear RNA and spliceosomal introns in Euglena gracilis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Splice site diversity and abundance of noncanonical introns in diplonemids (Diplonemea, Euglenozoa).RNA (New York, N.Y.) · 2025Article
- Exome Sequencing Analysis and Clinical Features of a Chinese Patient with 3M Syndrome and A Review of Literature.The application of clinical genetics · 2025Article
- Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryote.BMC biology · 2024Article
- Article
- Transcriptomic and genomic identification of spliceosomal genes fromActa biochimica et biophysica Sinica · 2023Article
- Heterotrophic euglenid Rhabdomonas costata resembles its phototrophic relatives in many aspects of molecular and cell biology.Scientific reports · 2021Article
- Order of removal of conventional and nonconventional introns from nuclear transcripts of Euglena gracilis.PLoS genetics · 2018Article
- Intermediate introns in nuclear genes of euglenids - are they a distinct type?BMC evolutionary biology · 2016Article
- Distribution of conventional and nonconventional introns in tubulin (α and β) genes of euglenids.Molecular biology and evolution · 2014Article
- Genomic characterization of Neoparamoeba pemaquidensis (Amoebozoa) and its kinetoplastid endosymbiont.Eukaryotic cell · 2011Article
- A possible role for short introns in the acquisition of stroma-targeting peptides in the flagellate Euglena gracilis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2010Article
- U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis.BMC genomics · 2009Article
- A high density of ancient spliceosomal introns in oxymonad excavates.BMC evolutionary biology · 2006Article
- An ancient spliceosomal intron in the ribosomal protein L7a gene (Rpl7a) of Giardia lamblia.BMC evolutionary biology · 2005Article
- Unusual features of fibrillarin cDNA and gene structure in Euglena gracilis: evolutionary conservation of core proteins and structural predictions for methylation-guide box C/D snoRNPs throughout the domain Eucarya.Nucleic acids research · 2005Article
- A spliceosomal intron in Giardia lamblia.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Spliceosomal introns in a deep-branching eukaryote: the splice of life.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Evolutionary appearance of genes encoding proteins associated with box H/ACA snoRNAs: cbf5p in Euglena gracilis, an early diverging eukaryote, and candidate Gar1p and Nop10p homologs in archaebacteria.Nucleic acids research · 2000Article
- A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA.RNA (New York, N.Y.) · 2000Article
- Viral and cellular mRNA capping: past and prospects.Advances in virus research · 2000Review
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
In the flagellated protozoon Euglena gracilis, characterized nuclear genes harbor atypical introns that usually are flanked by short repeats, adopt complex secondary structures in pre-mRNA, and do not obey the GT-AG rule of conventional cis-spliced introns. In the nuclear fibrillarin gene of E. gracilis, we have identified three spliceosomal-type introns that have GT-AG consensus borders. Furthermore, we have isolated a small RNA from E. gracilis and propose, on the basis of primary and secondary structure comparisons, that it is a homolog of U1 small nuclear RNA, an essential component of the cis-spliceosome in higher eukaryotes. Conserved sequences at the 5' splice sites of the fibrillarin introns can potentially base pair with Euglena U1 small nuclear RNA. Our observations demonstrate that spliceosomal GT-AG cis-splicing occurs in Euglena, in addition to the nonconventional cis-splicing and spliced leader trans-splicing previously recognized in this early diverging unicellular eukaryote.
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