ArticleThe Journal of experimental medicine1999
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 86 citations in OpenAlex.
- Immunological Phenotyping of Mice with a Point Mutation inBiomedicines · 2023Article
- Gene therapy for inborn errors of immunity: past, present and future.Nature reviews. Immunology · 2023Review
- Review
- Morphologic and Immunohistochemical Characterization of Spontaneous Lymphoma/Leukemia in NSG Mice.Veterinary pathology · 2020Article
- Developmental regulation of p53-dependent radiation-induced thymocyte apoptosis in mice.Clinical and experimental immunology · 2015Article
- Review
- Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.The Journal of experimental medicine · 2012Article
- Sequential administration of cytokine genes to enhance cellular immune responses and CD4 (+) T memory cells during DNA vaccination.Human vaccines & immunotherapeutics · 2012Article
- Synergistic effects of interleukin-7 and pre-T cell receptor signaling in human T cell development.The Journal of biological chemistry · 2012Article
- Thymocytes may persist and differentiate without any input from bone marrow progenitors.The Journal of experimental medicine · 2012Article
- CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia.The Journal of experimental medicine · 2009Article
- Characterization of the thymic IL-7 niche in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Homeostasis of naive T cells: the Foxo that fixes.Nature immunology · 2009Article
- Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Progression of regulatory gene expression states in fetal and adult pro-T-cell development.Immunological reviews · 2006Review
- Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells.Immunology · 2005Article
- IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.The Journal of experimental medicine · 2004Article
- Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.Molecular and cellular biology · 2002Article
- Article
- Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular signals emanating from cytokine and antigen receptors are integrated during the process of intrathymic development. Still, the relative contributions of cytokine receptor signaling to pre-T cell receptor (TCR) and TCR-mediated differentiation remain undefined. Interleukin (IL)-7 interactions with its cognate receptor complex (IL-7Ralpha coupled to the common cytokine receptor gamma chain, gammac) play a dominant role in early thymopoiesis. However, alpha/beta T cell development in IL-7-, IL-7Ralpha-, and gammac-deficient mice is only partially compromised, suggesting that additional pathways can rescue alpha/beta T lineage cells in these mice. We have investigated the potential interdependence of gammac- and pre-TCR-dependent pathways during intrathymic alpha/beta T cell differentiation. We demonstrate that gammac-dependent cytokines do not appear to be required for normal pre-TCR function, and that the rate-limiting step in alpha/beta T cell development in gammac- mice does not involve TCR-beta chain rearrangements, but rather results from poor maintenance of early thymocytes. Moreover, mice double mutant for both gammac and pre-Talpha show vastly reduced thymic cellularity and a complete arrest of thymocyte differentiation at the CD44(+)CD25(+) cell stage. These observations demonstrate that the pre-TCR provides the gammac-independent signal which allows alpha/beta T cell development in gammac- mice. Thus, a series of overlapping signals derived from cytokine and T cell receptors guide the process of alpha/beta thymocyte development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.