ArticleGenome research1999
Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review.Tissue engineering and regenerative medicine · 2017Review
- Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.Biology of reproduction · 2013Article
- Interleukin-1 beta influences on lysyl oxidases and matrix metalloproteinases profile of injured anterior cruciate ligament and medial collateral ligament fibroblasts.International orthopaedics · 2013Article
- Up-regulation expressions of lysyl oxidase family in Anterior Cruciate Ligament and Medial Collateral Ligament fibroblasts induced by Transforming Growth Factor-Beta 1.International orthopaedics · 2012Article
- Tumor suppressive effect of lysyl oxidase proenzyme.Biochimica et biophysica acta · 2009Article
- Improving the specificity of exon prediction using comparative genomics.BMC genomics · 2008Article
- Experimental validation of novel genes predicted in the un-annotated regions of the Arabidopsis genome.BMC genomics · 2007Article
- Gene structure prediction in syntenic DNA segments.Nucleic acids research · 2003Article
- Strong conservation of the human NF2 locus based on sequence comparison in five species.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Leveraging the mouse genome for gene prediction in human: from whole-genome shotgun reads to a global synteny map.Genome research · 2003Article
- Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine.Genome research · 2002Article
- An invasion-independent pathway of blood-borne metastasis: a new murine mammary tumor model.The American journal of pathology · 2002Article
- Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.Genome research · 2001Article
- Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.Genome research · 2001Article
- Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.Genome research · 2001Article
- Human and mouse gene structure: comparative analysis and application to exon prediction.Genome research · 2000Article
- Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.Genome research · 2000Article
- PipMaker--a web server for aligning two genomic DNA sequences.Genome research · 2000Article
- Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The mnd2 mutation on mouse chromosome 6 produces a progressive neuromuscular disorder. To determine the gene content of the 400-kb mnd2 nonrecombinant region, we sequenced 108 kb of mouse genomic DNA and 92 kb of human genomic sequence from the corresponding region of chromosome 2p13.3. Three genes with the indicated sizes and intergenic distances were identified: D6Mm5e (>/=81 kb)-787 bp-DOK (2 kb)-845 bp-LOR2 (>/=6 kb). D6Mm5e is expressed in many tissues at very low abundance and the predicted 526-residue protein contains no known functional domains. DOK encodes the p62(dok) rasGAP binding protein involved in signal transduction. LOR2 encodes a novel lysyl oxidase-related protein of 757 amino acid residues. We describe a simple search protocol for identification of conserved internal exons in genomic sequence. Evolutionary conservation proved to be a useful criterion for distinguishing between authentic exons and artifactual products obtained by exon amplification, RT-PCR, and 5' RACE. Conserved noncoding sequence elements longer than 80 bp with >/=75% nucleotide sequence identity comprise approximately 1% of the genomic sequence in this region. Comparative analysis of this human and mouse genomic DNA sequence was an efficient method for gene identification and is independent of developmental stage or quantitative level of gene expression. [The sequence data described in this paper have been submitted to the GenBank data library under the following accession numbers: AC003061, mouse BAC clone 245c12; AC003065, human BAC clone h173(E10); AF053368, mouse Lor2 cDNA; AF084363, 108-kb contig from mouse BAC 245c12; AF084364, mouse D6Mm5e cDNA.]
Indexed as
Identifiers
9927484PMC310704W1832870753What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.