Evidence map›Paper›PMID 9927471›Full record

ArticleGenetics1999

A second-generation genetic linkage map of the domestic dog, Canis familiaris.

M W Neff, K W Broman, C S Mellersh, K Ray, G M Acland, G D Aguirre, J S Ziegle, E A Ostrander, J Rine

Open access · hybridAbstract read
In one paragraph

Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 214 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

M W NeffDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
K W Broman
C S Mellersh
K Ray
G M Acland
G D Aguirre
J S Ziegle
E A Ostrander
J Rine
Cornell University · USFred Hutch Cancer Center · USUniversity of California, Berkeley · USMarshfield Clinic · US

Funding

MODELS OF HEREDITY RETINAL DEGENERATIONR01EY006855 · NEI · UNIVERSITY OF PENNSYLVANIA · PI GUSTAVO David AGUIRRE, William A. Beltran · 1992 to 2026
$20.7M
CANINE MODELS OF HEREDITARY RETINAL DEGENERATIONSU01EY006855 · NEI · UNIVERSITY OF PENNSYLVANIA · PI AGUIRRE, GUSTAVO DAVID · 1986 to 1992
–
NEI NIH HHS EY-06855NIGMS NIH HHS 1F32GM16262-01
6 · The paper itself

Abstract

Purebred strains, pronounced phenotypic variation, and a high incidence of heritable disease make the domestic dog uniquely suited to complement genetic analyses in humans and mice. A comprehensive genetic linkage map would afford many opportunities in dogs, ranging from the positional cloning of disease genes to the dissection of quantitative differences in size, shape, and behavior. Here we report a canine linkage map with the number of mapped loci expanded to 276 and 10-cM coverage extended to 75-90% of the genome. Most of the 38 canine autosomes are likely represented in the collection of 39 autosomal linkage groups. Eight markers were sufficiently informative to detect linkage at distances of 10-13 cM, yet remained unlinked to any other marker. Taken together, the results suggested a genome size of about 27 M. As in other species, the genetic length varied between sexes, with the female autosomal distance being approximately 1.4-fold greater than that of male meioses. Fifteen markers anchored well-described genes on the map, thereby serving as landmarks for comparative mapping in dogs. We discuss the utility of the current map and outline steps necessary for future map improvement.

Indexed as

Chromosome MappingGenetic LinkageGenomeAnimalsDogsFemaleGenetic MarkersHumansMaleMicePedigreeGenetic Markers

Identifiers

PMID9927471
PMCPMC1460484
OpenAlexW2095824574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.