ArticleGenetics1999
High-frequency retrotransposition of a marked I factor in Drosophila melanogaster correlates with a dynamic expression pattern of the ORF1 protein in the cytoplasm of oocytes.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Integrated mechanism for the generation of the 5' junctions of LINE inserts.Nucleic acids research · 2014Article
- Specific activation of an I-like element in Drosophila interspecific hybrids.Genome biology and evolution · 2014Article
- Confinement of gene drive systems to local populations: a comparative analysis.Journal of theoretical biology · 2012Article
- Self-interaction, nucleic acid binding, and nucleic acid chaperone activities are unexpectedly retained in the unique ORF1p of zebrafish LINE.Molecular and cellular biology · 2012Article
- Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions.Mobile DNA · 2010Article
- A bioinformatics search pipeline, RNA2DSearch, identifies RNA localization elements in Drosophila retrotransposons.RNA (New York, N.Y.) · 2009Article
- A branching process for the early spread of a transposable element in a diploid population.Journal of mathematical biology · 2008Article
- An epigenetic role for maternally inherited piRNAs in transposon silencing.Science (New York, N.Y.) · 2008Article
- piRNA-mediated nuclear accumulation of retrotransposon transcripts in the Drosophila female germline.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- The first steps of transposable elements invasion: parasitic strategy vs. genetic drift.Genetics · 2005Article
- In vivo RNA localization of I factor, a non-LTR retrotransposon, requires a cis-acting signal in ORF2 and ORF1 protein.Nucleic acids research · 2005Article
- Targeted nuclear import of open reading frame 1 protein is required for in vivo retrotransposition of a telomere-specific non-long terminal repeat retrotransposon, SART1.Molecular and cellular biology · 2004Article
- Chimeric RNA transposition intermediates of the I factor produce precise retrotransposed copies.Nucleic acids research · 2002Article
- Element-specific localization of Drosophila retrotransposon Gag proteins occurs in both nucleus and cytoplasm.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Artificial and epigenetic regulation of the I factor, a nonviral retrotransposon of Drosophila melanogaster.Genetics · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the expression of the I factor, a non-long-terminal-repeat retrotransposon responsible for I-R hybrid dysgenesis in Drosophila melanogaster, we have tagged the ORF1 protein (ORF1p) by inserting the HA epitope in its N-terminal region. In transgenic flies, this modification is compatible with a high rate of autonomous transposition and allows direct estimation of the transposition frequency. I factor transposes in the germline of females (SF) that are daughters from crosses between I strain males (which contain active copies of the I factor) and R strain females (which do not). We analyzed the expression pattern of ORF1p by indirect immunofluorescence. Its expression correlates with retrotransposition. During oogenesis ORF1p appears unexpectedly as a cytoplasmic product, which accumulates with a specific pattern into the oocyte. A comparison of the expression patterns under conditions that modify the transposing activity of the element clarifies some aspects of I-factor functioning in the transposition process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.