ArticleGenetics1999
Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 153 citations in OpenAlex.
- Article
- Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration.Genes & development · 2026Article
- Intrinsically weak sex chromosome drive through sequential asymmetric meiosis.Science advances · 2025Article
- Advances in PIWI-piRNA function in female reproduction in mammals.Acta biochimica et biophysica Sinica · 2024Review
- Challenges and Opportunities Arising from Host-International journal of molecular sciences · 2024Review
- Regulation of insect behavior by non-coding RNAs.Science China. Life sciences · 2024Review
- Non-gonadal somatic piRNA pathways ensure sexual differentiation, larval growth, and wing development in silkworms.PLoS genetics · 2023Article
- TheCells · 2022Article
- Expression of Extracellular Vesicle PIWI-Interacting RNAs Throughout hiPSC-Cardiomyocyte Differentiation.Frontiers in physiology · 2022Article
- RDC complex executes a dynamic piRNA program during Drosophila spermatogenesis to safeguard male fertility.PLoS genetics · 2021Article
- piRNA-mediated gene regulation and adaptation to sex-specific transposon expression inGenes & development · 2021Article
- Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation.Life science alliance · 2021Article
- Assembly and Function of Gonad-Specific Non-Membranous Organelles inNon-coding RNA · 2019Review
- dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster.International journal of molecular sciences · 2017Review
- The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila.RNA (New York, N.Y.) · 2016Article
- Novel mutants of the aubergine gene.Fly · 2016Article
- The piRNA Pathway Guards the Germline Genome Against Transposable Elements.Advances in experimental medicine and biology · 2016Review
- The cellular basis of hybrid dysgenesis and Stellate regulation in Drosophila.Current opinion in genetics & development · 2015Review
- Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper.Molecular cell · 2015Article
- A conserved upstream motif orchestrates autonomous, germline-enriched expression of Caenorhabditis elegans piRNAs.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sting mutation, caused by a P element inserted into polytene region 32D, was isolated by a screen for male sterile insertions in Drosophila melanogaster. This sterility is correlated with the presence of crystals in spermatocytes and spermatids that are structurally indistinguishable from those produced in males carrying a deficiency of the Y-linked crystal (cry) locus. In addition, their morphology is needle-like in Ste+ flies and star-shaped in Ste flies, once again as observed in cry- males. The sti mutation leads to meiotic drive of the sex chromosomes, and the strength of the phenomenon is correlated with the copy number of the repetitive Ste locus. The same correlation is also true for the penetrance of the male sterile mutation. A presumptive sti null allele results in male sterility and lethal maternal effect. The gene was cloned and shown to code for a putative protein that is 866 amino acids long. A C-terminal domain of 82 amino acids is identified that is well conserved in proteins from different organisms. The gene is expressed only in the germline of both sexes. The interaction of sting with the Ste locus can also be demonstrated at the molecular level. While an unprocessed 8-kb Ste primary transcript is expressed in wild-type males, in X/Y homozygous sti males, as in X/Y cry- males, a 0.7-kb mRNA is produced.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.