ArticleGenetics1999
Identification of genes controlling malpighian tubule and other epithelial morphogenesis in Drosophila melanogaster.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels.Nature communications · 2026Article
- The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut.Hereditas · 2020Article
- Identifying Genetic Players in Cell Sheet Morphogenesis Using aG3 (Bethesda, Md.) · 2018Article
- Loci Contributing to Boric Acid Toxicity in Two Reference Populations ofG3 (Bethesda, Md.) · 2017Article
- Drosophila as a model for epithelial tube formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
- Non-apoptotic function of apoptotic proteins in the development of Malpighian tubules of Drosophila melanogaster.Journal of biosciences · 2011Article
- Drosophila provides rapid modeling of renal development, function, and disease.American journal of physiology. Renal physiology · 2010Review
- Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster.The Journal of experimental biology · 2009Review
- Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development.Developmental biology · 2005Article
- pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos.Genes & development · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The Drosophila Malpighian tubule is a model system for studying genetic mechanisms that control epithelial morphogenesis. From a screen of 1800 second chromosome lethal lines, by observing uric acid deposits in unfixed inviable embryos, we identified five previously described genes (barr, fas, flb, raw, and thr) and one novel gene, walrus (wal), that affect Malpighian tubule morphogenesis. Phenotypic analysis of these mutant embryos allows us to place these genes, along with other previously described genes, into a genetic pathway that controls Malpighian tubule development. Specifically, wal affects evagination of the Malpighian tubule buds, fas and thr affect bud extension, and barr, flb, raw, and thr affect tubule elongation. In addition, these genes were found to have different effects on development of other epithelial structures, such as foregut and hindgut morphogenesis. Finally, from the same screen, we identified a second novel gene, drumstick, that affects only foregut and hindgut morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.