ArticleThe EMBO journal1999
Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 116 citations in OpenAlex.
- Long-term major histocompatibility complex class I suppression in astronauts and clinical implications.Communications biology · 2026Review
- A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation.Frontiers in immunology · 2024Article
- Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells.FEBS open bio · 2023Article
- Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.Frontiers in immunology · 2021Review
- Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway.Critical reviews in biochemistry and molecular biology · 2019Review
- Moving the Cellular Peptidome by Transporters.Frontiers in cell and developmental biology · 2018Review
- A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins.The Journal of biological chemistry · 2013Article
- Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription.Journal of virology · 2011Article
- State of the art and challenges in sequence based T-cell epitope prediction.Immunome research · 2010Article
- What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Immunologic research · 2010Review
- Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules.The EMBO journal · 2009Article
- Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.Cell host & microbe · 2009Article
- MHC class I antigen presentation: learning from viral evasion strategies.Nature reviews. Immunology · 2009Review
- Redox-regulated export of the major histocompatibility complex class I-peptide complexes from the endoplasmic reticulum.Molecular biology of the cell · 2009Article
- MHC class I assembly: out and about.Trends in immunology · 2008Review
- Viral proteins interfering with antigen presentation target the major histocompatibility complex class I peptide-loading complex.Journal of virology · 2008Review
- Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells.Cancer immunology, immunotherapy : CII · 2008Article
- The convergent roles of tapasin and HLA-DM in antigen presentation.Trends in immunology · 2008Review
- Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection.The EMBO journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presentation of antigen-derived peptides by major histocompatibility complex (MHC) class I molecules is dependent on an endoplasmic reticulum (ER) resident glycoprotein, tapasin, which mediates their interaction with the transporter associated with antigen processing (TAP). Independently of TAP, tapasin was required for the presentation of peptides targeted to the ER by signal sequences in MHC class I-transfected insect cells. Tapasin increased MHC class I peptide loading by retaining empty but not peptide-containing MHC class I molecules in the ER. Upon co-expression of TAP, this retention/release function of tapasin was sufficient to reconstitute MHC class I antigen presentation in insect cells, thus defining the minimal non-housekeeping functions required for MHC class I antigen presentation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.