ArticleThe EMBO journal1999
TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Silencing the Circadian Clock GenesInsects · 2025Article
- Reflections on Several Landmark Advances in Circadian Biology.Journal of circadian rhythms · 2024Review
- Splicing the Clock to Maintain and Entrain Circadian Rhythms.Journal of biological rhythms · 2019Review
- Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.Molecules and cells · 2019Article
- Spliceosome factors target timeless (eLife · 2018Article
- CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.Scientific reports · 2016Article
- Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.PLoS genetics · 2015Article
- Functional circadian clock genes are essential for the overwintering diapause of the Northern house mosquito, Culex pipiens.The Journal of experimental biology · 2015Article
- Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.Nucleic acids research · 2014Article
- A role for Drosophila ATX2 in activation of PER translation and circadian behavior.Science (New York, N.Y.) · 2013Article
- Speed control: cogs and gears that drive the circadian clock.Trends in neurosciences · 2012Review
- Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein.The Journal of biological chemistry · 2011Article
- The novel gene twenty-four defines a critical translational step in the Drosophila clock.Nature · 2011Article
- Article
- Modeling brain dynamics using computational neurogenetic approach.Cognitive neurodynamics · 2008Article
- Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1).Genes & development · 2007Article
- PSEUDO-RESPONSE REGULATOR 7 and 9 are partially redundant genes essential for the temperature responsiveness of the Arabidopsis circadian clock.The Plant cell · 2005Article
- Novel insights into the regulation of the timeless protein.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap.Molecular biology of the cell · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The timeless protein (TIM) is a central component of the circadian pacemaker machinery of the fruitfly Drosophila melanogaster. Both TIM and its partner protein, the period protein PER, show robust circadian oscillations in mRNA and protein levels. Yet the role of TIM in the rhythm generation mechanism is largely unknown. To analyze TIM function, we constructed transgenic flies that carry a heat shock-inducible copy of the timeless gene (tim) in an arrhythmic tim loss-of-function genetic background. When heat shocked, TIM levels in these flies rapidly increased and initiated a molecular cycle of PER accumulation and processing with dynamics very similar to the PER cycle observed in wild-type flies. Analysis of period (per) mRNA levels and transcription uncovered a novel role for TIM in clock regulation: TIM increases per mRNA levels through a post-transcriptional mechanism. Our results suggest positive as well as negative autoregulation in the Drosophila circadian clock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.