ArticleThe EMBO journal1999
Cytokinesis mediated through the recruitment of cortexillins into the cleavage furrow.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Queue Gaps Among the IQGAPs inInternational journal of molecular sciences · 2026Review
- Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity.Nature communications · 2025Article
- Microtubule dependent sorting of actin-binding proteins in mitosis.Scientific reports · 2024Article
- Wound Repair of the Cell Membrane: Lessons fromCells · 2024Review
- Expanding ring-shaped cleavage furrows in multinucleate cells.Molecular biology of the cell · 2023Article
- The lectin Discoidin I acts in the cytoplasm to help assemble the contractile machinery.The Journal of cell biology · 2022Article
- Patterning of the cell cortex and the localization of cleavage furrows in multi-nucleate cells.Journal of cell science · 2022Article
- An altered transcriptome underliesFrontiers in genetics · 2022Article
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- Coefficient of variation as an image-intensity metric for cytoskeleton bundling.Scientific reports · 2020Article
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- Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Quantitative imaging of Rac1 activity in Dictyostelium cells with a fluorescently labelled GTPase-binding domain from DPAKa kinase.Histochemistry and cell biology · 2016Article
- A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement.Nature communications · 2015Article
- Three-dimensional balance of cortical tension and axial contractility enables fast amoeboid migration.Biophysical journal · 2015Article
- The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases.Cellular and molecular life sciences : CMLS · 2014Article
- Biochemical and biological properties of cortexillin III, a component of Dictyostelium DGAP1-cortexillin complexes.Molecular biology of the cell · 2014Article
- Evolution and cell physiology. 3. Using Dictyostelium discoideum to investigate mechanisms of epithelial polarity.American journal of physiology. Cell physiology · 2013Review
- α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium.Developmental cell · 2012Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fact that substrate-anchored Dictyostelium cells undergo cytokinesis in the absence of myosin II underscores the importance of other proteins in enabling the cleavage furrow to constrict. Cortexillins, a pair of actin-bundling proteins, are required for normal cleavage. They are targeted to the incipient furrow in wild-type and, more prominently, in myosin II-null cells. No other F-actin bundling or cross-linking protein tested is co-localized. Green fluorescent protein fusions show that the N-terminal actin-binding domain of cortexillin I is dispensable and the C-terminal region is sufficient for translocation to the furrow and the rescue of cytokinesis. Cortexillins are suggested to have a targeting signal for coupling to a myosin II-independent system that directs transport of membrane proteins to the cleavage furrow.
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