ArticleOncogene1999
WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- ACell genomics · 2022Article
- Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization.Frontiers in oncology · 2020Article
- Potency of Human Urine-Derived Stem Cells for Renal Lineage Differentiation.Tissue engineering and regenerative medicine · 2017Article
- Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation.Oncotarget · 2017Article
- N -Methyl- N -nitrosourea-induced Renal Tumors in Rats: Immunohistochemical Comparison to Human Wilms Tumors.Journal of toxicologic pathology · 2013Article
- A mutant Ahr allele protects the embryonic kidney from hydrocarbon-induced deficits in fetal programming.Environmental health perspectives · 2011Article
- WT1/EGR1-mediated control of STIM1 expression and function in cancer cells.Frontiers in bioscience (Landmark edition) · 2011Review
- Noncytotoxic differentiation treatment of renal cell cancer.Cancer research · 2011Article
- Lack of α8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells.BMC cell biology · 2010Article
- Serine threonine receptor-associated protein (STRAP) plays a role in the maintenance of mesenchymal morphology.Cellular signalling · 2010Article
- A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.Neoplasia (New York, N.Y.) · 2008Article
- Versican mediates mesenchymal-epithelial transition.Molecular biology of the cell · 2006Article
- Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.Oncogene · 2002Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The WT1 tumor suppressor gene, implicated in hereditofamilial and sporadic Wilms' tumor, is required for normal renal development and is up-regulated during the mesenchymal-epithelial transition. NIH3T3 fibroblasts overexpressing WT1 were less proliferative, larger in size and more firmly attached to tissue culture plastic, suggesting an alteration of their state of differentiation. These cells were studied in vivo by subcutaneous injection into nude mice. The resulting tumors exhibited epithelioid histopathology and formed desmosome-like structures. Molecular analyses of these WT1 expressing fibroblasts grown in culture and in nude mice revealed significant alterations in the expression of many kidney epithelial markers. These studies indicate that WT1 expression can initiate features of a program of epithelial differentiation consistent with a prominent role for WT1 in the mesenchymal epithelial transition that occurs during renal development. Through this work we identified a number of novel target genes for the WT1 transcription factor, including uvomorulin, integrin alpha8 and perlecan, and suggest that WTI may activate the IGF-II gene, also implicated in the development of Wilms' tumor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.