ArticleOncogene1999
Anti-apoptotic function of Rac in hematopoietic cells.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 88 citations in OpenAlex.
- Aberrant Rac pathway signalling in glioblastoma.Small GTPases · 2021Review
- Functional Verification of NovelFrontiers in cell and developmental biology · 2021Article
- Increased mortality and aggravation of heart failure in liver X receptor-α knockout mice after myocardial infarction.Heart and vessels · 2016Article
- Cellular Stress and p53-Associated Apoptosis by Juniperus communis L. Berry Extract Treatment in the Human SH-SY5Y Neuroblastoma Cells.International journal of molecular sciences · 2016Article
- The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.The Journal of biological chemistry · 2015Article
- Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation.Cell reports · 2014Article
- Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction.Journal of the American Heart Association · 2014Article
- Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development.Journal of the American Heart Association · 2014Article
- COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP.Oncogenesis · 2012Article
- Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis.International journal of oncology · 2012Article
- Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.Developmental biology · 2011Article
- The role of FilGAP-filamin A interactions in mechanoprotection.Molecular biology of the cell · 2009Article
- Cytotoxic necrotizing factor 1 prevents apoptosis via the Akt/IkappaB kinase pathway: role of nuclear factor-kappaB and Bcl-2.Molecular biology of the cell · 2007Article
- Article
- Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts.Arthritis research & therapy · 2006Article
- Clozapine inhibits cell survival-related genes in bone marrow cells.Molecular psychiatry · 2004Article
- Differential interaction and activation of Rho family GTPases by p210bcr-abl and p190bcr-abl.Oncogene · 2003Article
- Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells.Molecular and cellular biology · 2003Article
- Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway.Oncogene · 2002Article
- Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB.Oncogene · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The small GTP-binding protein Rac plays a pivotal role in the regulation of diverse physiological events including reorganization of the actin cytoskeleton, cell cycle progression, and transformation. Here we show an anti-apoptotic effect of Rac in interleukin-3-dependent murine hematopoietic BaF3 cells. Activated Rac(G12V), when ectopically expressed in BaF3 cells, rendered the cells resistant to apoptosis upon interleukin-3 deprivation, while activated mutants of Rho and Cdc42 displayed no significant anti-apoptotic effect. In contrast to activated Ras, which also supports cell survival in the absence of interleukin-3, Rac required fetal bovine serum for the prevention of cell death. The involvement of phosphatidylinositol 3-kinase downstream of Rac was demonstrated by the inhibition of Rac-induced cell survival by wortmannin and LY294002 and the presence of phosphatidylinositol kinase activity in the Rac immunoprecipitate. Furthermore, the serine/threonine kinase Akt was stimulated by activated Rac and fetal bovine serum in a synergistic manner. Rac-induced Akt activation was mediated by phosphorylation of threonine-308 and serine-473. In addition to the phosphatidylinositol 3-kinase/Akt pathway, the p38 mitogen-activated protein kinase pathway was crucial for Rac-dependent survival, whereas p38 mitogen-activated protein kinase nas not implicated in Ras-induced anti-apoptotic signaling. These findings provide evidence for the involvement of Rac in survival signaling of hematopoietic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.