ArticleOncogene1999
Elf3 encodes a novel 200-kD beta-spectrin: role in liver development.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
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- SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.Theranostics · 2021Article
- The role of βII spectrin in cardiac health and disease.Life sciences · 2018Review
- Transforming growth factor-β in liver cancer stem cells and regeneration.Hepatology communications · 2017Review
- PRAJA is overexpressed in glioblastoma and contributes to neural precursor development.Genes & cancer · 2017Article
- TGF-β signaling in liver and gastrointestinal cancers.Cancer letters · 2016Review
- CEACAM1 long cytoplasmic domain isoform is associated with invasion and recurrence of hepatocellular carcinoma.Annals of surgical oncology · 2014Article
- Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.Journal of cellular and molecular medicine · 2012Article
- Cell organization, growth, and neural and cardiac development require αII-spectrin.Journal of cell science · 2011Article
- The mechanism of TGF-β signaling during palate development.Oral diseases · 2011Review
- Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer.Hepatology (Baltimore, Md.) · 2011Article
- Growth factor- and cytokine-driven pathways governing liver stemness and differentiation.World journal of gastroenterology · 2010Article
- Histology atlas of the developing mouse hepatobiliary system with emphasis on embryonic days 9.5-18.5.Toxicologic pathology · 2010Article
- The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life.Protoplasma · 2010Review
- Cardiac spectrins: alternative splicing encodes functional diversity.Journal of molecular and cellular cardiology · 2010Article
- Cancer stem cells and hepatocellular carcinoma.Cancer biology & therapy · 2009Review
- Role of Radiation-induced TGF-beta Signaling in Cancer Therapy.Molecular and cellular pharmacology · 2009Article
- Liver stem cells and hepatocellular carcinoma.Hepatology (Baltimore, Md.) · 2009Review
- Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis.Hepatology (Baltimore, Md.) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
beta-spectrins are crucial for the maintenance of cell shape, the establishment of cell polarity, and the formation of distinct membrane domains. Our strategy for identifying genes important for hepatocyte polarity has been to utilize subtractive hybridization of early embryonic mouse cDNA liver libraries. As a result, we have cloned three isoforms of a novel beta-spectrin elf (embryonic liver beta-fodrin), and here we report the analysis of elf3, the longest isoform (8172 nt). ELF3 comprises 2154 residues with an overall similarity of 89.0% and 95.3% to mouse beta-spectrin (betaSpIIsigma1) at the nucleotide and amino acid level, respectively. ELF3 is characterized by an actin-binding domain, a long repeat domain, and a short regulatory domain remarkable for the absence of a PH domain. Linkage analysis reveals that elf3 maps to mouse chromosome 11 between D11Bir6 and D11Xrf477, a different chromosomal locus from that of the other four spectrin genes. Northern blot analysis utilizing an elf3 3'-UTR probe demonstrates an abundant 9.0-kb transcript in brain, liver, and heart tissues. Western blot with a polyclonal antibody against ELF identifies a 200 kD protein in mouse liver, brain, kidney, and heart tissues. Immunohistochemical studies demonstrate ELF labeling of the basolateral or sinusoidal membranes surface as well as a granular cytoplasmic pattern in hepatocytes. Antisense studies utilizing cultured liver explants show a vital role of elf3 in hepatocyte differentiation and intrahepatic bile duct formation. The differential expression, tissue localization, and functional studies demonstrate the importance of elf3 in modulating interactions between various components of the cytoskeleton proteins controlling liver and bile duct development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.