ArticleOncogene1999
p53 inhibits entry into mitosis when DNA synthesis is blocked.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
- Genome homeostasis defects drive enlarged cells into senescence.Molecular cell · 2023Article
- Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53.Oncogene · 2022Article
- Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner.The Journal of biological chemistry · 2014Article
- DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p(34)cdc2: Role of p53.Mutation research · 2013Article
- Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides.The Journal of pharmacology and experimental therapeutics · 2010Article
- p53 regulates mtDNA copy number and mitocheckpoint pathway.Journal of carcinogenesis · 2009Article
- DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Hbo1 Links p53-dependent stress signaling to DNA replication licensing.Molecular and cellular biology · 2008Article
- p53 mediates senescence-like arrest induced by chronic replicational stress.Molecular and cellular biology · 2007Article
- Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53.Oncogene · 2007Article
- Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells.Cancer cell international · 2006Article
- p53 protects from replication-associated DNA double-strand breaks in mammalian cells.Oncogene · 2004Article
- Article
- Replication of damaged DNA in vitro is blocked by p53.Nucleic acids research · 2003Article
- Stabilization of p53 and transactivation of its target genes in response to replication blockade.Oncogene · 2002Article
- Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability.Molecular and cellular biology · 2001Article
- Regulation of the G2/M transition by p53.Oncogene · 2001Review
- p53 accumulates but is functionally impaired when DNA synthesis is blocked.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Human and mouse fibroblasts with normal p53 fail to enter mitosis when DNA synthesis is blocked by aphidicolin or hydroxyurea. Isogenic p53-null fibroblasts do enter mitosis with incompletely replicated DNA, revealing that p53 contributes to a checkpoint that ensures that mitosis does not occur until DNA synthesis is complete. When treated with N-(phosphonacetyl)-L-aspartate (PALA), which inhibits pyrimidine nucleotide synthesis, leading to synthesis of damaged DNA from highly unbalanced dNTP pools, p53-null cells enter mitosis after they have completed DNA replication, but cells with wild-type p53 do not, revealing that p53 also mediates a checkpoint that monitors the quality of newly replicated DNA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.