ArticleOncogene1999
Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 89 citations in OpenAlex.
- Lack of Paxillin phosphorylation promotes single-cell migration in vivo.The Journal of cell biology · 2023Article
- Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice.Toxicologic pathology · 2023Article
- Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss.Scientific reports · 2021Article
- Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.International review of cell and molecular biology · 2020Article
- Identification and Analysis of Dysfunctional Genes and Pathways in CD8Frontiers in genetics · 2020Article
- Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX.Scientific reports · 2019Article
- A one-step procedure to probe the viscoelastic properties of cells by Atomic Force Microscopy.Scientific reports · 2018Article
- Amniotic membrane promotes focal adhesion remodeling to stimulate cell migration.Scientific reports · 2017Article
- Deregulation of focal adhesion formation and cytoskeletal tension due to loss of A-type lamins.Cell adhesion & migration · 2017Article
- Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation.The Journal of biological chemistry · 2017Article
- FAK and paxillin, two potential targets in pancreatic cancer.Oncotarget · 2016Review
- Research advances on structure and biological functions of integrins.SpringerPlus · 2016Review
- Role played by paxillin and paxillin tyrosine phosphorylation in hepatocyte growth factor/sphingosine-1-phosphate-mediated reactive oxygen species generation, lamellipodia formation, and endothelial barrier function.Pulmonary circulation · 2015Article
- Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Expression of paxillin in laryngeal squamous cell carcinoma and its prognostic value.International journal of clinical and experimental pathology · 2015Article
- Text mining and network analysis of molecular interaction in non-small cell lung cancer by using natural language processing.Molecular biology reports · 2014Article
- Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.Journal of cell science · 2014Article
- Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer.Journal of translational medicine · 2013Article
- c-Jun N-Terminal Kinases Mediate a Wide Range of Targets in the Metastatic Cascade.Genes & cancer · 2013Review
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Lung cancer can lead to abnormalities of the actin cytoskeleton structure which may be important in transformation. In this study, we have investigated the expression of the cytoskeletal associated protein paxillin in lung cancer. Paxillin is a 68 kDa focal adhesion protein, with four tandem LIM domains at the C-terminus, involved in growth factor receptor, integrin and oncogenic signaling such as v-src, BCR/ABL, and E6 of the papilloma virus. In non-small cell lung cancer (NSCLC) cell lines, paxillin localized to the focal adhesions. The possible role of paxillin in lung cancer cells was assessed by overexpressing green fluorescence protein (GFP)-paxillin construct in two separate NSCLC cell lines (Calu-1 and H661). Over the course of 48 h, GFP-paxillin consistently caused the cells to become round and to decrease cell motility as compared to normal controls, GFP-N-terminus paxillin, or GFP-LIM transfected cells. Because some lung cancers may be quite aggressive and metastasize quickly, which may be related to the cytoskeleton, we determined the expression of paxillin in NSCLC and small cell lung cancer (SCLC) cell lines and patient tumor tissues. Expression of paxillin in NSCLC and SCLC cell lines were determined by Northern blot and Western blot analysis. The expression of paxillin was consistently low in SCLC cell lines, whereas there was paxillin expression in NSCLC cell lines. There was a variability of expression of paxillin in NSCLC tumor tissue as compared to normal lung tissue. In contrast, by immunohistochemistry, we show that there was no detectable expression of paxillin in 5/5 SCLC patients. This data suggests that absence or low level of paxillin protein expression may cause certain lung cancers, such as SCLC, to be more motile and possibly more aggressive.
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