ArticleThe Journal of physiology1999
Role of adenosine in regulating glucose uptake during contractions and hypoxia in rat skeletal muscle.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- Effect of Dipyridamole Injected for Myocardial Perfusion Imaging on Blood Glucose Concentration; A Preliminary Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Glucose homeostasis during short-term and prolonged exposure to high altitudes.Endocrine reviews · 2015Review
- Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity.Journal of diabetes and metabolic disorders · 2014Article
- Article
- Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.American journal of physiology. Endocrinology and metabolism · 2009Article
- Contraction-related factors affect the concentration of a kallidin-like peptide in rat muscle tissue.The Journal of physiology · 2002Article
- Glucose, exercise and insulin: emerging concepts.The Journal of physiology · 2001Review
- Caffeine ingestion does not alter carbohydrate or fat metabolism in human skeletal muscle during exercise.The Journal of physiology · 2000Article
- F-18 fluorodeoxyglucose imaging in myocardial ischemia: beyond myocardial viability.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effect of A1-adenosine receptor antagonism via 8-cyclopentyl-1,3-dipropyl-xanthine (CPDPX) on the stimulation of skeletal muscle glucose uptake by contractions and hypoxia was investigated in isolated perfused rat hindquarters. The standard perfusate contained either no insulin or a submaximal insulin concentration at 100 microU ml-1. 2. Muscles were stimulated to contract for 45 min by intermittent tetanic stimulation of the sciatic nerve. Hypoxia was induced by reducing perfusate haematocrit from 30% to 10% on the one hand, and by switching the gassing of the perfusate from a 35% to a 0% O2 mixture for 60 min on the other hand. The effect of contractions and hypoxia alone, or in combination, was investigated. 3. Hypoxia-induced muscle glucose uptake was not altered by CPDPX in the absence or presence of insulin. In contrast, contraction-induced glucose uptake was reduced by approximately 25 % (P < 0.05) by exposure of muscles to CPDPX. CPDPX did not affect hindlimb glucose uptake either before or after contractions. 4. The increment of muscle glucose uptake during hypoxia combined with contractions was greater (P < 0.05) than the effect of hypoxia alone. 5. The current findings provide evidence that the mechanism by which hypoxia stimulates muscle glucose uptake is, at least in part, different from the mechanism of glucose uptake stimulation by contractions, because (i) A1-adenosine receptors regulate insulin-mediated glucose uptake in muscle during contractions but not during hypoxia and (ii) submaximal hypoxia and contractions are additive stimuli to muscle glucose uptake.
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Registered trials
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