ArticleAntimicrobial agents and chemotherapy1999
Activity of a heat-induced reformulation of amphotericin B deoxycholate (fungizone) against Leishmania donovani.
Article in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Unpacking amphotericin B toxicity: a critical review of amphotericin B aggregation and its link to toxicity and antifungal activity.Archives of toxicology · 2026Review
- To heat or not to heat: the impact of temperature on the aggregation state of amphotericin B in drug delivery systems.Nanomedicine (London, England) · 2024Article
- Article
- Liposomal Amphotericin B for Treatment of Leishmaniasis: From the Identification of Critical Physicochemical Attributes to the Design of Effective Topical and Oral Formulations.Pharmaceutics · 2022Review
- Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity.Asian journal of pharmaceutical sciences · 2022Article
- Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy.Pharmaceutics · 2020Review
- Biomimetically engineered Amphotericin B nano-aggregates circumvent toxicity constraints and treat systemic fungal infection in experimental animals.Scientific reports · 2017Article
- Influence of the freeze-drying process on the physicochemical and biological properties of pre-heated amphotericin B micellar systems.AAPS PharmSciTech · 2014Article
- Antileishmanial activity, uptake, and biodistribution of an amphotericin B and poly(α-Glutamic Acid) complex.Antimicrobial agents and chemotherapy · 2013Article
- How can micelle systems be rebuilt by a heating process?International journal of nanomedicine · 2012Article
- Anti-trypanosomatid activity of ceragenins.The Journal of parasitology · 2010Article
- Production and characterization of stable amphotericin-resistant amastigotes and promastigotes of Leishmania mexicana.Antimicrobial agents and chemotherapy · 2005Article
- Treatment of experimental visceral leishmaniasis with amphotericin B in stable albumin microspheres.Antimicrobial agents and chemotherapy · 2004Article
- Heat-treated Fungizone retains amphotericin B antifungal activity without renal toxicity in rats infected with Aspergillus fumigatus.Pharmaceutical research · 2004Article
- Effect of heat-treated amphotericin B on renal and fungal cytotoxicity.Antimicrobial agents and chemotherapy · 2004Article
- Toxicity and antileishmanial activity of a new stable lipid suspension of amphotericin B.Antimicrobial agents and chemotherapy · 2003Article
- The effect of serum albumin on amphotericin B aggregate structure and activity.Pharmaceutical research · 2001Article
- Clinical and experimental advances in treatment of visceral leishmaniasis.Antimicrobial agents and chemotherapy · 2001Review
- Heat treatment of amphotericin b modifies its serum pharmacokinetics, tissue distribution, and renal toxicity following administration of a single intravenous dose to rabbits.Antimicrobial agents and chemotherapy · 2001Article
- Mild heating of amphotericin B-desoxycholate: effects on ultrastructure, in vitro activity and toxicity, and therapeutic efficacy in severe candidiasis in leukopenic mice.Antimicrobial agents and chemotherapy · 2000Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.
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