ArticleSexually transmitted infections1998
Isolation and characterisation of T lymphocytes from the urethra of patients with acute urethritis.
Article in Sexually transmitted infections, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Detection of functional antigen-specific T cells from urine of non-muscle invasive bladder cancer patients.Oncoimmunology · 2012Article
- Chlamydia trachomatis-specific human CD8+ T cells show two patterns of antigen recognition.Infection and immunity · 2004Article
- HLA-B27 expression does not modulate intracellular Chlamydia trachomatis infection of cell lines.Infection and immunity · 2001Article
- Why common things are common: the tale of non-gonococcal urethritis.Sexually transmitted infections · 2001Article
- Peripheral blood T cell proliferative response to chlamydial organisms in gonococcal and non-gonococcal urethritis and presumed pelvic inflammatory disease.Sexually transmitted infections · 1999Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate local cellular immune responses in patients with acute urethritis.
methodsWe have established T cell lines from the urethral exudate and examined their phenotype by flow cytometry. As controls, T cell lines were cultured from first pass urine specimens of asymptomatic healthy individuals.
resultsUsing interleukin 2 (IL-2) alone a T cell line was obtained on only one occasion. Following culture with IL-2, and subsequent expansion by a single stimulation with irradiated allogenic peripheral blood mononuclear cells (PBMC), phytohaemagglutinin (PHA), and IL-2, it was possible to establish T cell lines from 6/6 acute urethritis patients. T cell lines were also obtained from 4/12 controls subjects, but required repetitive rounds of stimulation with mitogen and allogeneic PBMC to produce sufficient cell numbers for analysis. Three of the patient T cell lines were dominated by T cells expressing the gamma delta receptor.
conclusionThe gamma delta T cell subset has been associated with immune responses at mucosal surfaces and has the ability to recognise certain bacterial antigens. The gamma delta T cell response may represent an important aspect of the immune response to organisms associated with acute urethritis.
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Registered trials
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