ArticleThe British journal of ophthalmology1998
Cyclosporin A therapy in refractory non-infectious childhood uveitis.
Article in The British journal of ophthalmology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis.Rheumatology international · 2012Guideline
- Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry.Pediatric rheumatology online journal · 2016Trial
- Trial
- High-dose daclizumab for the treatment of juvenile idiopathic arthritis-associated active anterior uveitis.American journal of ophthalmology · 2009Trial
- Management Strategies of Juvenile Idiopathic Arthritis-Associated Chronic Anterior Uveitis: Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Update on biologic therapies for juvenile idiopathic arthritis-associated uveitis.Annals of eye science · 2021Article
- Paediatric non-infectious uveitis in Cape Town, South Africa: a retrospective review of disease characteristics and outcomes on immunomodulating treatment.Pediatric rheumatology online journal · 2021Observational
- Recent advances in the management of non-infectious posterior uveitis.International ophthalmology · 2020Review
- An Update on Treatment of Pediatric Chronic Non-Infectious Uveitis.Current treatment options in rheumatology · 2017Article
- Juvenile idiopathic arthritis-associated uveitis.Pediatric rheumatology online journal · 2016Review
- Uveitis in Children: Diagnosis and Management.Indian journal of pediatrics · 2016Review
- Uveitis associated with juvenile idiopathic arthritis.Nature reviews. Rheumatology · 2015Review
- [Therapy of intermediate uveitis].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2014Article
- Pediatric uveitis: new and future treatments.Current opinion in ophthalmology · 2013Review
- Response of pediatric uveitis to tumor necrosis factor-α inhibitors.The Journal of rheumatology · 2013Article
- Current concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation.Eye (London, England) · 2012Review
- Challenges of childhood uveitis.Sultan Qaboos University medical journal · 2009Article
- Non-infectious pediatric uveitis: an update on immunomodulatory management.Paediatric drugs · 2009Review
- Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-up.American journal of ophthalmology · 2007Article
- Biological response modifier therapy for refractory childhood uveitis.The British journal of ophthalmology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess the immunosuppressive efficacy, steroid sparing effect and adverse effects of cyclosporin A (CsA) therapy in refractory non-infectious childhood uveitis.
methodsA retrospective case series review of the medical records of children on CsA therapy attending a tertiary referral centre for refractory endogenous uveitis was performed. Low dose (< or = 5.0 mg/kg/day) CsA therapy was started either as monotherapy or in combination with other agents. The CsA immunosuppressive efficacy was assessed by visual acuity and binocular indirect ophthalmoscopy (BIO) score outcomes and steroid sparing effect by growth charts and ability to withdraw or maintain a low steroid dose. Possible CsA adverse effects were monitored by routine biochemistry (including serum creatinine) and haematological tests, blood pressure recordings, and symptoms.
results14 patients (25 eyes, 10 males, four females) were recruited with steroid failure as the most common CsA indication. Age (mean (SD)) at start of CsA therapy was 8.7 (4.1) years with a duration of CsA therapy of 20.9 (range 3.5-88.3) months at a maintenance CsA dose of 4.0 (1.0) mg/kg/day. From baseline, visual acuity improved or was maintained in 23 (92%) eyes and BIO score improved in 19 (76%) eyes. Height centiles were preserved and the maintenance prednisolone dose was 6.3 (3.3) mg/day, where required, in 10 (71%) patients. Nephrotoxicity was not observed, with transient systemic hypertension developing in one patient. Minor adverse effects were more common but were well tolerated.
conclusionsCyclosporin A therapy is effective and safe in the medium term, if closely monitored, in refractory non-infectious childhood uveitis.
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Registered trials
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