ArticleAnnals of the rheumatic diseases1998
Synovial mast cell responses during clinical improvement in early rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 90 citations in OpenAlex.
- Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm.Clinical reviews in allergy & immunology · 2025Review
- Common autoimmune diseases and urticaria: the causal relationship from a bidirectional two-sample mendelian randomization study.Frontiers in immunology · 2023Article
- Review
- Molecular and Cellular Heterogeneity in Rheumatoid Arthritis: Mechanisms and Clinical Implications.Frontiers in immunology · 2021Review
- Mast Cells: Fascinating but Still Elusive after 140 Years from Their Discovery.International journal of molecular sciences · 2020Article
- Roles of mast cells in rheumatoid arthritis.The Korean journal of internal medicine · 2020Review
- Persistence of Mast Cell-Positive Synovitis in Early Rheumatoid Arthritis Following Treatment With Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs.Frontiers in pharmacology · 2020Article
- Mast Cells in Early Rheumatoid Arthritis.International journal of molecular sciences · 2019Review
- Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress.Frontiers in immunology · 2018Review
- The Autoimmune Skin Disease Bullous Pemphigoid: The Role of Mast Cells in Autoantibody-Induced Tissue Injury.Frontiers in immunology · 2018Review
- Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5.The Journal of biological chemistry · 2017Article
- Vitamin E slows down the progression of osteoarthritis.Experimental and therapeutic medicine · 2016Article
- Activated mast cells promote differentiation of B cells into effector cells.Scientific reports · 2016Article
- Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice.British journal of pharmacology · 2010Article
- Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis.Clinical rheumatology · 2007Article
- Mast cells in rheumatoid arthritis.Clinical rheumatology · 2007Review
- Human umbilical cord blood-derived mast cells: a unique model for the study of neuro-immuno-endocrine interactions.Stem cell reviews · 2006Review
- Mast cells in inflammatory arthritis.Arthritis research & therapy · 2005Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the synovial mast cell response in early rheumatoid arthritis (RA) during clinical improvement, and to examine for relations with clinical and histological parameters of disease activity.
methodsTwenty two synovial samples were obtained from six patients with RA using needle arthroscopy. The mean disease duration at baseline was eight months, and two to three further samples were obtained over a mean follow up period of 15 months during which treatment initiated clinical improvement occurred. Sections were immunostained to detect MCT and MCTC mast cells and correlations were sought between clinical and histological data.
resultsThe overall mean synovial mast cell density was 40.3 cells/mm2, with regional densities of 60.6 and 34.2 mast cells/mm2 in the superficial and deeper synovial layers respectively. The MCT subset predominated, outnumbering MCTC by 3:1. There was a significant correlation between the histological inflammation index and the MCT density, (r = 0.4, p < 0.05) but not the MCTC subset. The regional distribution and predominant subset of mast cells varied in individual patient's synovia over time, with a trend towards restriction of the mast cell response to the superficial synovium during clinical improvement.
conclusionsThe mast cell response in early RA is characterised by substantial expansion of predominantly MCT mast cells that correlates with histological indices of inflammation. During clinical improvement, this expansion tended to become more superficial. Taken together with previous studies of long duration RA, which implicate MCTC cells in synovial damage and disease progression, these results suggest that MCT and MCTC mast cells may possess distinct functions in the spectrum of inflammatory events occurring during RA.
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