Trial reportAnnals of surgery1999
A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns.
Trial report in Annals of surgery, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137254 (Effects of Insulin on Post Burn Hypermetabolism), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Insulin on Post Burn Hypermetabolism
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 235 citations in OpenAlex.
- Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis.Diabetologia · 2016Pooled it
- Predictors of muscle protein synthesis after severe pediatric burns.The journal of trauma and acute care surgery · 2015Trial
- Early rehabilitative exercise training in the recovery from pediatric burn.Medicine and science in sports and exercise · 2014Trial
- Amino acid infusion fails to stimulate skeletal muscle protein synthesis up to 1 year after injury in children with severe burns.The journal of trauma and acute care surgery · 2013Trial
- Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial.American journal of respiratory and critical care medicine · 2010Trial
- Control of hyperglycaemia in paediatric intensive care (CHiP): study protocol.BMC pediatrics · 2010Trial
- The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life support.Annals of surgery · 2006Trial
- Glucose-lipid ratio is a determinant of nitrogen balance during total parenteral nutrition in critically ill patients: a prospective, randomized, multicenter blind trial with an intention-to-treat analysis.Intensive care medicine · 2005Trial
- Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury.Annals of surgery · 2005Trial
- Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation.Journal of pediatric surgery · 2004Trial
- Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned.Annals of surgery · 2003Trial
- Gene expression patterns in skeletal muscle of thermally injured children treated with oxandrolone.Annals of surgery · 2003Trial
- Beta-blockade and growth hormone after burn.Annals of surgery · 2002Trial
- Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment.Annals of surgery · 1999Trial
- Metformin is associated with reduced risk of mortality and morbidity in burn patients compared to insulin.Burns : journal of the International Society for Burn Injuries · 2024Article
- Nutrition in Pediatric Burns.Seminars in plastic surgery · 2024Review
- Metabolic response to burn injury: a comprehensive bibliometric study.Frontiers in medicine · 2024Article
- Glucose Metabolism in Burns-What Happens?International journal of molecular sciences · 2021Review
- Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology.Frontiers in pediatrics · 2021Review
- Can lessons learned about preventing cardiac muscle death be applied to prevent skeletal muscle death?Bone & joint research · 2020Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the hypothesis that a submaximal insulin dose reverses the net muscle catabolism associated with severe burns, and to determine its effects on amino acid kinetics. SUMMARY BACKGROUND DATA: The authors previously showed that a maximal dose of insulin administered to patients with severe burns promoted skeletal muscle glucose uptake and net protein synthesis. However, this treatment was associated with caloric overload resulting from the large quantities of exogenous glucose required to maintain euglycemia, and hypoglycemia was a potential problem.
methodsThirteen patients were studied after severe burn injury (>60% total body surface area). Patients were randomly treated by standard care (n = 5) or with exogenous insulin (n = 8). Data were derived from an arteriovenous model with primed-continuous infusions of stable isotopes and biopsies of the vastus lateralis muscle.
resultsNet amino acid balance was significantly improved with insulin treatment. Skeletal muscle protein synthesis was significantly greater in the group receiving insulin, whereas muscle protein breakdown was not different between the groups. This submaximal dose of insulin did not affect glucose or amino acid uptake or require a greater caloric intake to avoid hypoglycemia.
conclusionsSubmaximal insulin can promote muscle anabolism without eliciting a hypoglycemic response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.