ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Neurotrophins support the development of diverse sensory axon morphologies.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 169 citations in OpenAlex.
- Muscle-selective RUNX3 dependence of sensorimotor circuit development.Development (Cambridge, England) · 2019Article
- A cell fitness selection model for neuronal survival during development.Nature communications · 2019Article
- The Role of Apoptotic Signaling in Axon Guidance.Journal of developmental biology · 2018Review
- Improving the glial differentiation of human Schwann-like adipose-derived stem cells with graphene oxide substrates.Interface focus · 2018Article
- Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Molecular neurobiology · 2017Review
- Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins.International journal of molecular sciences · 2017Article
- NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone.Cell reports · 2016Article
- Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study.Reproductive biology and endocrinology : RB&E · 2016Article
- Intrinsic Axonal Growth and the Drive for Regeneration.Frontiers in neuroscience · 2016Review
- Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer.Oncotarget · 2015Article
- Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study.Translational psychiatry · 2015Article
- Whole-mount imaging of mouse embryo sensory axon projections.Journal of visualized experiments : JoVE · 2014Article
- Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.The Journal of experimental medicine · 2014Article
- Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Neuronal development: SAD kinases make happy axons.Current biology : CB · 2013Article
- Null mutations of NT-3 and Bax affect trigeminal ganglion cell number but not brainstem barrelette pattern formation.Somatosensory & motor research · 2013Article
- SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.Neuron · 2013Article
- Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology.Cell and tissue research · 2013Article
- Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling.Frontiers in molecular neuroscience · 2012Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The initial outgrowth of peripheral axons in developing embryos is thought to occur independently of neurotrophins. However, the degree to which peripheral neurons can extend axons and elaborate axonal arborizations in the absence of these molecules has not been studied directly because of exquisite survival requirements for neurotrophins at early developmental stages. We show here that embryonic sensory neurons from BAX-deficient mice survived indefinitely in the absence of neurotrophins, even in highly dissociated cultures, allowing assessment of cell autonomous axon outgrowth. At embryonic day 11 (E11)-E13, stages of rapid axon growth toward targets in vivo, Bax-/- sensory neurons cultured without neurotrophins were almost invariably unipolar and extended only a rudimentary axon. Addition of neurotrophins caused outgrowth of a second axon and a marked, dose-dependent elongation of both processes. Surprisingly, morphological responses to individual neurotrophins differed substantially. Neurotrophin-3 (NT-3) supported striking terminal arborization of subsets of Bax-/- neurons, whereas NGF produced predominantly axon elongation in a different subset. We conclude that axon growth in vitro is neurotrophin dependent from the earliest stages of sensory neuron development. Furthermore, neurotrophins support the appearance of distinct axonal morphologies that characterize different sensory neuron subpopulations.
Indexed as
Identifiers
9920667PMC6782147W1564635029What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.