ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 76 citations in OpenAlex.
- Ageing in the brain: mechanisms and rejuvenating strategies.Cellular and molecular life sciences : CMLS · 2023Review
- Apoaequorin differentially modulates fear memory in adult and aged rats.Brain and behavior · 2020Article
- Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons.Frontiers in cellular neuroscience · 2020Article
- Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease.Behavioural brain research · 2017Review
- CA1 pyramidal cells have diverse biophysical properties, affected by development, experience, and aging.PeerJ · 2017Article
- Raised Intracellular Calcium Contributes to Ischemia-Induced Depression of Evoked Synaptic Transmission.PloS one · 2016Article
- Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains.The Journal of physiology · 2015Article
- L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle.PloS one · 2014Article
- Characterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation.Journal of neurophysiology · 2014Article
- Tools, methods, and applications for optophysiology in neuroscience.Frontiers in molecular neuroscience · 2013Article
- The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism.Hippocampus · 2012Article
- Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.Pigment cell & melanoma research · 2011Article
- Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization.Neurobiology of aging · 2009Article
- Enhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment.Journal of neurophysiology · 2009Article
- Calcium buffering systems and calcium signaling in aged rat basal forebrain neurons.Aging cell · 2007Review
- Electrotonic coupling between stratum oriens interneurones in the intact in vitro mouse juvenile hippocampus.The Journal of physiology · 2004Article
- The contribution of intracellular calcium stores to mEPSCs recorded in layer II neurones of rat barrel cortex.The Journal of physiology · 2002Article
- Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of membrane-permeant Ca2+ chelators on field EPSPs (fEPSPs) were measured in the hippocampal CA1 region of brain slices from young (2-4 months) and old (24-27 months) Fischer 344 rats. BAPTA-AM depressed fEPSPs in young slices by up to 70% but enhanced fEPSPs by 30% in aged slices. EGTA-AM, with slower binding kinetics, did not affect fEPSPs from young slices but enhanced fEPSPs in aged slices. BAPTA derivatives with calcium dissociation constants (Kd) of 0.2-3.5 microM reduced or enhanced fEPSPs in young and aged slices, respectively, but 5',5'-dinitro BAPTA-AM (Kd of approximately 7000 microM) had no effect. Frequency facilitation of the fEPSPs occurred in young, but not in aged, slices, except when BAPTA-AM or EGTA-AM was perfused onto aged slices. The differential effects of BAPTA-AM in young and old slices were eliminated by perfusing with a low Ca2+-high Mg2+ saline or with the calcium blocker Co2+. These data suggest that intracellular Ca2+ regulation is altered and raised in aged neurons. Cell-permeant calcium buffers may be able to "ameliorate" deficits in synaptic transmission in the aged brain.
Indexed as
Identifiers
9920654PMC6782130W2120905810What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.