ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire1999
Pathogenesis of porcine Actinobacillus pleuropneumonia, part II: roles of proinflammatory cytokines.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Comparative therapeutic effect of steroidal and non-steroidal anti-inflammatory drugs on pro-inflammatory cytokine production in water buffalo calves (Bubalus bubalis) naturally infected with bronchopneumonia: a randomized clinical trial.Tropical animal health and production · 2017Trial
- Review
- MicroRNA-127 promotes anti-microbial ability in porcine alveolar macrophages via S1PR3/TLR signaling pathway.Journal of veterinary science · 2023Article
- Respiratory viral infections drive different lung cytokine profiles in pigs.BMC veterinary research · 2021Article
- Article
- In vivo testing of novel vaccine prototypes against Actinobacillus pleuropneumoniae.Veterinary research · 2018Article
- Transcriptional profiling of hilar nodes from pigs after experimental infection with Actinobacillus pleuropneumoniae.International journal of molecular sciences · 2013Article
- Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1β, IL-8 and TNF-α in porcine alveolar macrophages.Veterinary research · 2011Article
- Acute-phase proteins: As diagnostic tool.Journal of pharmacy & bioallied sciences · 2011Article
- Characterization of pneumonia due to Streptococcus equi subsp. zooepidemicus in dogs.Clinical and vaccine immunology : CVI · 2010Article
- Expression levels of immune markers in Actinobacillus pleuropneumoniae infected pigs and their relation to breed and clinical symptoms.BMC veterinary research · 2009Article
- Molecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarrays.Acta veterinaria Scandinavica · 2007Article
- Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae.Clinical and diagnostic laboratory immunology · 2004Article
- In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome but rewarding.Veterinary immunology and immunopathology · 2002Review
- Immunology of the porcine respiratory disease complex.The Veterinary clinics of North America. Food animal practice · 2001Review
- Interleukin-10 gene therapy-mediated amelioration of bacterial pneumonia.Infection and immunity · 2000Article
- Rapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs.Veterinary researchArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vitro production of proinflammatory cytokines after stimulation with Actinobacillus pleuropneumoniae and the relation of these cytokines in vivo with the disease caused by A. pleuropneumoniae were investigated. Within 24 h, in vitro stimulation by A. pleuropneumoniae (serotype 1) preparations, including killed bacteria, bacterial culture supernatant, lipopolysaccharide, and bacterial extracts, porcine pulmonary alveolar macrophages (PAM) produced significant (P < 0.05) amounts of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) as measured by bioassays. The supernatants containing interleukin-8 from PAM after stimulation by bacterial preparations showed significant neutrophil chemotaxis, while bacterial preparations alone did not. After in vivo infection with A. pleuropneumoniae, the mean levels of TNF-alpha and IL-1 in serum, as measured by bioassays, were elevated 37- to 27836-fold for TNF-alpha and 11- to 5941-fold higher for IL-1 within 4 d post-infection, depending on the treatments, and remained elevated up to Day 7. Both cytokines were also detected in porcine lungs by bioassays and immunocytochemistry. The results indicated that both secreted and surface components of A. pleuropneumoniae can stimulate PAM to produce proinflammatory mediators. Neutrophil chemoattractants rather than bacterial components are the major factor causing acute lung inflammation. The elevation of TNF-alpha and IL-1 in pigs occurred coincident with the onset of acute clinical disease.
Indexed as
Identifiers
9918337PMC1189518W1547043798What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.