ArticleThe American journal of pathology1999
Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 191 citations in OpenAlex.
- Anterograde and Retrograde Propagation of Inoculated Human Tau Fibrils and Tau Oligomers in a Non-Transgenic Rat Tauopathy Model.Biomedicines · 2023Article
- Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy.Frontiers in neuroscience · 2023Review
- Article
- FTD-associated mutations in Tau result in a combination of dominant and recessive phenotypes.Neurobiology of disease · 2022Article
- Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.International journal of molecular sciences · 2022Article
- Cellular and pathological heterogeneity of primary tauopathies.Molecular neurodegeneration · 2021Review
- Relevance of host tau in tau seeding and spreading in tauopathies.Brain pathology (Zurich, Switzerland) · 2020Article
- Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hereditary spastic paraplegia: gain-of-function mechanisms revealed by new transgenic mouse.Human molecular genetics · 2019Article
- rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.The Journal of experimental medicine · 2019Article
- What is the evidence that tau pathology spreads through prion-like propagation?Acta neuropathologica communications · 2017Review
- Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.JAMA neurology · 2017Article
- Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.Scientific reports · 2017Article
- Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.Frontiers in neuroscience · 2017Review
- The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells.Journal of diabetes research · 2016Article
- The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem.Frontiers in neurology · 2013Review
- Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Is tau ready for admission to the prion club?Prion · 2012Review
- Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model.International journal of Alzheimer's disease · 2012Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have generated transgenic mice expressing the shortest human tau protein, the microtubule-associated protein that composes paired helical filaments in Alzheimer's disease. Transgenic tau transcripts and proteins were strongly expressed in neurons in the developing and adult brain. In contrast to the endogenous tau that progressively disappeared from neuronal cell bodies during development, the human transgenic tau remained abundant in cell bodies and dendrites of a subset of neurons in the adult. This somatodendritic transgenic tau was immunoreactive with antibodies to tau phosphorylated on Thr181 and Thr231 and with the conformation-dependent Alz50 antibody. A few astrocytes expressing the transgenic tau were strongly immunoreactive with antibodies to additional tau phosphorylation sites, ie, at Ser262/ 356 and Ser396/404. All of these phosphorylation sites have been identified in paired helical filaments-tau proteins. In electron microscopy, the transgenic tau was detected into microtubules in axons and in dendrites but not in cell bodies. Neurofibrillary tangles were not detected in transgenic animals examined up to the age of 19 months. These results indicate that transgenic manipulation of tau expression and intracellular targeting is sufficient per se to affect tau compartmentalization, phosphorylation, and conformation partly as it is observed at the pretangle stage in Alzheimer's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.