ArticleThe American journal of pathology1999
Monoclonality of atypical adenomatous hyperplasia of the lung.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2011Pooled it
- Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma.Cell reports · 2022Article
- The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy.Cancer research · 2019Article
- Editorial comments for the circular RNA circPRKCI promotion of tumor growth in lung adenocarcinoma.Journal of thoracic disease · 2019Article
- Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.International journal of molecular sciences · 2018Review
- Increased expressions of claudin 4 and 7 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.Medical molecular morphology · 2016Article
- C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma.World journal of clinical oncology · 2014Review
- Allelic losses on chromosome 3p are accumulated in relation to morphological changes of lung adenocarcinoma.British journal of cancer · 2004Article
- A novel, essential control for clonality analysis with human androgen receptor gene polymerase chain reaction.The American journal of pathology · 2002Article
- Preneoplastic lesions of the lung.Respiratory research · 2002Review
- Article
- Pulmonary preinvasive neoplasia.Journal of clinical pathology · 2001Review
- The association between atypical adenomatous hyperplasia and primary lung cancer.British journal of cancer · 2000Article
- The clonal origin and clonal evolution of epithelial tumours.International journal of experimental pathology · 2000Review
- Early glandular neoplasia of the lung.Respiratory research · 2000Review
- Clonal analysis of adenosquamous carcinoma of the lung.Japanese journal of cancer research : Gann · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical adenomatous hyperplasia (AAH) of the lung has been postulated as a possible precursor lesion of bronchioloalveolar carcinoma (BAC). The clonality of AAHs from seven female patients was analyzed to determine whether AAH is a monoclonal expansion. All AAHs were identified in lungs surgically resected for BAC. The clonality of the BAC and bronchiolar metaplasia in each case was also analyzed. Approximately 500 cells in each lesion were precisely microdissected from methanol-fixed sections. Adjacent normal lung tissue was collected as a normal control. DNA was extracted for clonal analysis based on an X-chromosome-linked polymorphic marker, the human androgen receptor gene (HUMARA). HUMARA was found to be amplified with or without previous digestion by the methylation-sensitive restriction endonuclease Hpa II. Five cases were informative. All 10 AAHs and 7 BACs obtained from the informative cases showed monoclonality, whereas the control cells showed polyclonality. Three different AAH lesions in a single case showed both possible patterns of monoclonality. BAC and contiguous AAH showed identical monoclonality in two cases. Two lesions of bronchiolar metaplasia, which was considered reactive, were polyclonal. Our results demonstrated the monoclonal nature of AAH, and this finding suggests that AAH is a precursor of BAC or a preneoplastic condition.
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