ArticleThe American journal of pathology1999
Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 81 citations in OpenAlex.
- Differences in Clinical and Biological Features Between Type I and Type II Tumors in FIGO Stages I-II Epithelial Ovarian Carcinoma.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2015Article
- Cell-cycle protein expression in a population-based study of ovarian and endometrial cancers.Frontiers in oncology · 2015Article
- OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets.Molecular cancer · 2014Article
- Decreased P27 protein expression is correlated with the progression and poor prognosis of nasopharyngeal carcinoma.Diagnostic pathology · 2013Article
- Nuclear p27 expression confers a favorable outcome for nasopharyngeal carcinoma patients.Disease markers · 2013Article
- Predictive and prognostic protein biomarkers in epithelial ovarian cancer: recommendation for future studies.Cancers · 2010Article
- Cyclin-dependent kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer.Journal of cancer research and clinical oncology · 2006Article
- Clinico-prognostic value of D-type cyclins and p27 in laryngeal cancer patients: a review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2005Review
- Cip/Kip cell-cycle inhibitors: a neuro-oncological perspective.Journal of neuro-oncology · 2001Review
- Prognostic Significance of p27, Ki-67, and Topoisomerase lla Expression in Clinically Nonfunctioning Pancreatic Endocrine Tumors.Endocrine pathology · 2000Article
- Effect of Dopamine Agonists on Lactotroph Adenomas of the Human Pituitary.Endocrine pathology · 2000Article
- Cyclin dependent kinase inhibitor p27Kip1 expression in normal and neoplastic cervical epithelium.Journal of clinical pathology · 1999Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This case-control study was designed to identify factors associated with long-term survival. We examined two groups of patients with epithelial ovarian cancer, one group of long-term survivors (> 5 years) and one group of short-term survivors (< 2 years), for levels of expression of p53 and p27KIP1 proteins (as both proteins have been shown to be independent prognostic markers in tumors other than ovary) and the relationship with patient survival. Our findings show that p27KIP1 expression, in contrast to p53 expression, is positively associated with long-term survival in univariate analysis (P = 0.001), in analyses stratified by residual disease (P = 0.02) or performance status (P = 0.02), the two strongest prognostic factors for ovarian cancer, as well as multivariate analysis (P = 0.002) adjusting simultaneously for age, tumor stage, residual disease, performance status, and grade of differentiation. Therefore, immunostaining for levels of p27KIP1 expression may have potential as a new prognostic factor in the management of ovarian cancer.
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