Evidence map›Paper›PMID 9916123›Full record

ArticleInfection and immunity1999

Polysaccharide binding potential of the human A2 or A18 kappa light chain homologues.

D C Reason, T C Wagner, V R Tang, K D Moulton, A H Lucas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

D C ReasonChildren's Hospital Oakland Research Institute, Oakland, California, USA. dreason@partatope.com
T C Wagner
V R Tang
K D Moulton
A H Lucas

Funding

HUMAN ANTIBODY REPERTOIRE TO H INFLUENZAE BR37AI025008 · NIAID · CHILDREN'S HOSPITAL &RES CTR AT OAKLAND · PI LUCAS, ALEXANDER H. · 1995 to 2004
$2.5M
Polysaccharide Antibody RepertoiresR01AI025008 · NIAID · SCRIPPS CLINIC AND RESEARCH FOUNDATION · PI LUCAS, ALEXANDER H. · 1987 to 2010
$2.0M
NIAID NIH HHS AI-25008NIAID NIH HHS R01 AI025008NIAID NIH HHS R37 AI025008
6 · The paper itself

Abstract

Antibodies having light (L) chains encoded by the kappaII-A2 variable region gene segment predominate in the human response to the Haemophilus influenzae type b polysaccharide (Hib PS). To determine whether the closely related homologue of the A2 gene, the kappaII-A18 gene, has the potential to contribute to the repertoire, we examined Hib PS binding to a series of recombinant Fab fragments having either A2 or A18 L chains isolated from a Hib PS-vaccinated adult. The ability to bind Hib PS resided exclusively with those Fab fragments having A2 and containing an insertional arginine at the variable-joining junction. Thus, despite the sequence similarity between A2 and A18, only A2 contributes to the canonical Hib PS paratope.

Indexed as

AdultAntibodies, BacterialBacterial CapsulesBase SequenceDNA, ComplementaryHaemophilus VaccinesHumansImmunoglobulin kappa-ChainsImmunoglobulin Variable RegionMolecular Sequence DataPolysaccharides, BacterialStructure-Activity RelationshipAntibodies, BacterialDNA, ComplementaryHaemophilus influenzae type b polysaccharide vaccineHaemophilus VaccinesImmunoglobulin kappa-ChainsImmunoglobulin Variable RegionPolysaccharides, Bacterial

Identifiers

PMID9916123
PMCPMC96419
OpenAlexW2140271897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.