ArticleInfection and immunity1999
Pseudomonas aeruginosa keratitis in knockout mice deficient in intercellular adhesion molecule 1.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Experimental biofilm models for pharmacokinetic and pharmacodynamic investigations: bridging in vitro, ex vivo and in vivo systems.The Journal of antimicrobial chemotherapy · 2026Review
- Kaempferol MitigatesPharmaceuticals (Basel, Switzerland) · 2025Article
- Foundational concepts in the biology of bacterial keratitis.Experimental eye research · 2021Review
- Regulation of LOX-1 on adhesion molecules and neutrophil infiltration in mouseInternational journal of ophthalmology · 2020Article
- Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced Keratitis.Investigative ophthalmology & visual science · 2016Article
- Topical neutralization of interleukin-17 during experimental Pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology.Infection and immunity · 2012Article
- VIP promotes resistance in the Pseudomonas aeruginosa-infected cornea by modulating adhesion molecule expression.Investigative ophthalmology & visual science · 2010Article
- Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitis.Investigative ophthalmology & visual science · 2007Article
- Effects of exogenous interleukin-6 during Pseudomonas aeruginosa corneal infection.Infection and immunity · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In this study, the role of intercellular adhesion molecule 1 (ICAM-1) in the pathogenesis of Pseudomonas aeruginosa keratitis was examined by using inbred ICAM-1-deficient knockout mice. These mice had significantly less (P </= 0.02) ocular disease than wild-type mice, suggesting that ICAM-1 contributes to a more severe disease response following P. aeruginosa infection.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.