ArticleInfection and immunity1999
Characterization of a novel methyl-accepting chemotaxis gene, dmcB, from the oral spirochete Treponema denticola.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Kanamycin Resistance Cassette for Genetic Manipulation of Treponema denticola.Applied and environmental microbiology · 2015Article
- Porphyromonas gingivalis Outer Membrane Vesicles Mediate Coaggregation and Piggybacking of Treponema denticola and Lachnoanaerobaculum saburreum.International journal of dentistry · 2013Article
- Treponema denticola interactions with host proteins.Journal of oral microbiology · 2012Article
- Virulence factors of the oral spirochete Treponema denticola.Journal of dental research · 2011Review
- Transcriptional profiles of Treponema denticola in response to environmental conditions.PloS one · 2010Article
- Novel mechanism for conditional aerobic growth of the anaerobic bacterium Treponema denticola.Applied and environmental microbiology · 2008Article
- CheX is a phosphorylated CheY phosphatase essential for Borrelia burgdorferi chemotaxis.Journal of bacteriology · 2005Article
- Construction and characterization of a cheA mutant of Treponema denticola.Journal of bacteriology · 2002Article
- Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola.Infection and immunity · 2001Article
- Genetic and structural analyses of cytoplasmic filaments of wild-type Treponema phagedenis and a flagellar filament-deficient mutant.Journal of bacteriology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Immediately downstream from the previously isolated Treponema denticola ATCC 35405 prtB gene coding for a chymotrypsinlike protease activity, an open reading frame, ORF3, was identified which shared significant homology with the highly conserved domains (HCDs) of bacterial methyl-accepting chemotaxis proteins (MCPs). Nucleotide sequencing of this ORF revealed that the gene would code for a protein with a size of approximately 41 kDa. In addition, this sequence contained a domain which was virtually identical to the HCD of a recently characterized MCP, DmcA, of strain 35405. Therefore, this ORF was named dmcB. Northern blot analysis suggested that dmcB was part of an operon structure containing prtB. Insertional inactivation of dmcB utilizing an ermF-ermAM cassette resulted in a mutant with decreased chemoattraction toward nutrient supplements. In addition, the mutant displayed an altered pattern of methylated proteins under conditions of chemotaxis. Inactivation of the dmcB gene also attenuated the methylation of the DmcA protein. These results suggest that the dmcB gene codes for an MCP in T. denticola which may interact with other MCPs in these organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.