ArticleInfection and immunity1999
Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 151 citations in OpenAlex.
- Repeat Ascaris challenge reduces worm intensity through gastric cellular reprograming.PLoS neglected tropical diseases · 2025Article
- Dose-response effects of multiple Ascaris suum exposures and their impact on lung protection during larval ascariasis.PLoS neglected tropical diseases · 2024Article
- Human Ascaris infection is associated with higher frequencies of IL-10 producing B cells.PLoS neglected tropical diseases · 2024Article
- Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis.Frontiers in immunology · 2024Article
- Article
- In silico design of a polypeptide as a vaccine candidate against ascariasis.Scientific reports · 2023Article
- Excretory/Secretory Proteome of Females and Males of the HookwormPathogens (Basel, Switzerland) · 2023Article
- Human IgE mAbs identify major antigens of parasitic worm infection.The Journal of allergy and clinical immunology · 2022Article
- The FAR protein family of parasitic nematodes.PLoS pathogens · 2022Review
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance toParasitology · 2021Article
- Expression of Ascaris lumbricoides putative virulence-associated genes when infecting a human host.Parasites & vectors · 2021Article
- The long and winding road ofParasitology · 2021Article
- Diagnostic Potential of an IgE-ELISA in Detecting Strongyloidiasis.The American journal of tropical medicine and hygiene · 2020Article
- Whipworm and roundworm infections.Nature reviews. Disease primers · 2020Review
- IgE Levels toFrontiers in immunology · 2020Article
- Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice.PLoS neglected tropical diseases · 2016Article
- Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children putatively immune to the large roundworm Ascaris lumbricoides were identified in an area of Nigeria where infection is hyperendemic. Immunity was associated with higher levels of serum ferritin, C-reactive protein, and eosinophil cationic protein, indicating ongoing acute phase or inflammatory processes. In contrast, children who were susceptible to the infection had little serological evidence of inflammation despite their high parasite burdens. Immunoglobulin G (IgG) antibody activity in all subclasses was present in high titer in most children but appeared to have no protective function. Despite exceptionally high total IgE levels, there was no evidence that atopic responses to local common allergens was associated with natural immunity to Ascaris. Among those individuals who produced IgG antibody to recombinant ABA-1 allergen of Ascaris, the naturally immune group had significantly more IgE antibody to the allergen than did those susceptible to the infection. IgE antibody responses in conjunction with innate inflammatory processes therefore appear to associate with natural immunity to ascariasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.