ArticleAmerican journal of human genetics1999
Combined linkage and association sib-pair analysis for quantitative traits.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.Genetic epidemiology · 2013Pooled it
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- Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs.International journal of obesity (2005) · 2024Article
- Leveraging family data to design Mendelian randomization that is provably robust to population stratification.Genome research · 2023Article
- Leveraging family data to design Mendelian Randomization that is provably robust to population stratification.bioRxiv : the preprint server for biology · 2023Article
- Estimating effects of parents' cognitive and non-cognitive skills on offspring education using polygenic scores.Nature communications · 2022Article
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- Mendelian imputation of parental genotypes improves estimates of direct genetic effects.Nature genetics · 2022Article
- Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.Nature genetics · 2022Article
- Assortative mating and within-spouse pair comparisons.PLoS genetics · 2021Article
- Incorporating Polygenic Risk Scores in the ACE Twin Model to Estimate A-C Covariance.Behavior genetics · 2021Article
- Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion.Investigative ophthalmology & visual science · 2021Article
- Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs.PLoS genetics · 2020Article
- Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.Nature communications · 2020Article
- Candidate-gene association analysis for a continuous phenotype with a spike at zero using parent-offspring trios.Journal of applied statistics · 2020Article
- Causal relationships between lipid and glycemic levels in an Indian population: A bidirectional Mendelian randomization approach.PloS one · 2020Article
- Statistical power in genome-wide association studies and quantitative trait locus mapping.Heredity · 2019Article
- Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity.Functional & integrative genomics · 2019Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.