ArticleAmerican journal of human genetics1999
A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 267 citations in OpenAlex.
- Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.Molecular psychiatry · 2006Trial
- A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency.Molecular psychiatry · 2005Trial
- Support for EKN1 as the susceptibility locus for dyslexia on 15q21.Molecular psychiatry · 2004Trial
- Shared genetics between ADHD and reading/language abilities: Genome-wide correlations, stratified enrichment, cross-trait association, and mendelian randomization.JCPP advances · 2026Article
- Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts.PloS one · 2025Article
- Identifying interactive biological pathways associated with reading disability.Brain and behavior · 2020Article
- Decoding the biology of language and its implications in language acquisition.Journal of biosciences · 2019Review
- Cognitive genomics: Searching for the genetic roots of neuropsychological functioning.Neuropsychology · 2017Review
- Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.Human genetics · 2015Article
- Article
- Motor sequencing deficit as an endophenotype of speech sound disorder: a genome-wide linkage analysis in a multigenerational family.Psychiatric genetics · 2012Article
- Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2012Article
- DCDC2 genetic variants and susceptibility to developmental dyslexia.Psychiatric genetics · 2012Article
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- Approach to epigenetic analysis in language disorders.Journal of neurodevelopmental disorders · 2011Article
- Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond.Cell cycle (Georgetown, Tex.) · 2011Review
- PCSK6 is associated with handedness in individuals with dyslexia.Human molecular genetics · 2011Article
- Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia.Behavior genetics · 2011Article
- Genome scan for spelling deficits: effects of verbal IQ on models of transmission and trait gene localization.Behavior genetics · 2011Article
- In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.Behavior genetics · 2011Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent application of nonparametric-linkage analysis to reading disability has implicated a putative quantitative-trait locus (QTL) on the short arm of chromosome 6. In the present study, we use QTL methods to evaluate linkage to the 6p25-21.3 region in a sample of 181 sib pairs from 82 nuclear families that were selected on the basis of a dyslexic proband. We have assessed linkage directly for several quantitative measures that should correlate with different components of the phenotype, rather than using a single composite measure or employing categorical definitions of subtypes. Our measures include the traditional IQ/reading discrepancy score, as well as tests of word recognition, irregular-word reading, and nonword reading. Pointwise analysis by means of sib-pair trait differences suggests the presence, in 6p21.3, of a QTL influencing multiple components of dyslexia, in particular the reading of irregular words (P=.0016) and nonwords (P=.0024). A complementary statistical approach involving estimation of variance components supports these findings (irregular words, P=.007; nonwords, P=.0004). Multipoint analyses place the QTL within the D6S422-D6S291 interval, with a peak around markers D6S276 and D6S105 consistently identified by approaches based on trait differences (irregular words, P=.00035; nonwords, P=.0035) and variance components (irregular words, P=.007; nonwords, P=.0038). Our findings indicate that the QTL affects both phonological and orthographic skills and is not specific to phoneme awareness, as has been previously suggested. Further studies will be necessary to obtain a more precise localization of this QTL, which may lead to the isolation of one of the genes involved in developmental dyslexia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.