ArticleJapanese journal of cancer research : Gann1998
Phorbol ester-induced G1 arrest in BALB/MK-2 mouse keratinocytes is mediated by delta and eta isoforms of protein kinase C.
Article in Japanese journal of cancer research : Gann, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Protein kinase C signaling and cell cycle regulation.Frontiers in immunology · 2012Article
- YueF overexpression inhibits cell proliferation partly through p21 upregulation in renal cell carcinoma.International journal of molecular sciences · 2011Article
- Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium.Journal of cancer research and clinical oncology · 2007Review
- Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex.Molecular and cellular biology · 2004Article
- Stimulation of protein kinase C-dependent and -independent signaling pathways by bistratene A in intestinal epithelial cells.Biochemical pharmacology · 2001Article
- PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes.Oncogene · 2000Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
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Abstract
We investigated the possible negative regulation of the cell cycle by protein kinase C (PKC) isoforms in synchronously grown BALB/MK-2 mouse keratinocytes, in which PKC isoforms were overexpressed by using the adenovirus vector Ax. Cells at the G1/S boundary of the cell cycle were the most sensitive to the inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC agonist, resulting in G1 arrest. TPA-induced inhibition of DNA synthesis was augmented by overexpression of the eta and delta isoforms, but rescued by the dominant-negative and antisense eta isoforms. In contrast, the alpha and zeta isoforms showed no effect on DNA synthesis with or without TPA treatment. Immunoblotting indicated cell cycle-dependent expression of the eta isoform, being highest in cells at the G1/S boundary. The present study provides evidence that the eta and delta isoforms of PKC are involved in negative regulation of cell cycle at the G1/S boundary in mouse keratinocytes.
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