ReviewMolecular pathology : MP1998
Genomic imprinting and cancer.
Review in Molecular pathology : MP, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Autophagy inhibition by TSSC4 (tumor suppressing subtransferable candidate 4) contributes to sustainable cancer cell growth.Autophagy · 2022Article
- Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis.Disease models & mechanisms · 2022Article
- Tumor Suppressing Subtransferable Candidate 4 Expression Prevents Autophagy-Induced Cell Death Following Temozolomide Treatment in Glioblastoma Cells.Frontiers in cell and developmental biology · 2022Article
- Epigenetic modifications at DMRs of placental genes are subjected to variations in normal gestation, pathological conditions and folate supplementation.Scientific reports · 2017Article
- Article
- Stability of genomic imprinting in human induced pluripotent stem cells.BMC genetics · 2013Article
- Rare allelic forms of PRDM9 associated with childhood leukemogenesis.Genome research · 2013Article
- High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method.BMC medical genomics · 2012Article
- Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting.Epigenetics · 2010Article
- Oncoviruses and Pathogenic MicroRNAs in Humans.The open virology journal · 2009Article
- Article
- Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- NUP98 gene fusions in hematologic malignancies.Leukemia · 2001Review
- The IGF/IGFBP system in CNS malignancy.Molecular pathology : MP · 2001Review
- An evaluation of evidence for the carcinogenic activity of bisphenol A.Reproductive toxicology (Elmsford, N.Y.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Genomic imprinting is the phenomenon by which individual alleles of certain genes are expressed differentially according to their parent of origin. The alleles appear to be differentially marked during gametogenesis or during the early part of development. This mark is heritable but reversible from generation to generation, implying a stable epigenetic modification. Approximately 25 imprinted genes have been identified to date, and dysregulation of a number of these has been implicated in tumour development. The normal physiological role of many imprinted genes is in the control of cell proliferation and fetal growth, indicating potential mechanisms of action in tumour formation. Both dominant and recessive modes of action have been postulated for the role of imprinted genes in neoplasia, as a result of effective gene dosage alterations by epigenetic modification of the normal pattern of allele specific transcription. The aim of this review is to assess the importance of imprinted genes in generating tumours and to discuss the implications for novel mechanisms of transforming mutation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.