ArticleImmunology1998
Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation.
Article in Immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 100 citations in OpenAlex.
- Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice.International journal of molecular sciences · 2023Article
- Effect of Ylang-Ylang (Molecules (Basel, Switzerland) · 2022Article
- STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice.Cells · 2021Article
- High Serum Levels of iNOS and MIP-1α are Associated with Post-Stroke Depression.Neuropsychiatric disease and treatment · 2021Article
- Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophagesFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Nitric Oxide Therapy for Diabetic Wound Healing.Advanced healthcare materials · 2019Review
- Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.Nature communications · 2018Article
- Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages.Acta pharmacologica Sinica · 2018Article
- Gender-differences of in vitro colonic motility after chemo- and radiotherapy in humans.BMC pharmacology & toxicology · 2018Article
- Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.Scientific reports · 2017Article
- Assessment of Phenolic Compounds and Anti-Inflammatory Activity of Ethyl Acetate Phase of Anacardium occidentale L. Bark.Molecules (Basel, Switzerland) · 2016Article
- Ouabain Modulates Zymosan-Induced Peritonitis in Mice.Mediators of inflammation · 2015Article
- Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis.Clinical reviews in allergy & immunology · 2013Review
- Neurogenesis of retinal ganglion cells is not essential to visual functional recovery after optic nerve injury in adult zebrafish.PloS one · 2013Article
- Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction.PloS one · 2013Article
- Resolvin D1 reduces the immunoinflammatory response of the rat eye following uveitis.Mediators of inflammation · 2012Article
- The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties.The American journal of pathology · 2011Article
- Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis.Bioorganic & medicinal chemistry · 2011Review
- Involvement of nitric oxide in a rat model of carrageenin-induced pleurisy.Mediators of inflammation · 2010Article
- Effects of nitric oxide on neutrophil influx depends on the tissue: role of leukotriene B4 and adhesion molecules.British journal of pharmacology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
In the present study, by comparing the responses in wild-type mice and mice lacking the inducible (or type 2) nitric oxide synthase (iNOS), we investigated the role played by iNOS in the regulation of polymorphonuclear granulocyte (PMN) accumulation and chemokine production in the mouse peritoneal cavity in response to administration of zymosan (0.2 mg). Zymosan injection induced the production of nitric oxide, and triggered a time-dependent PMN immigration into the peritoneal cavity. This response was associated with increases in the level of the chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-2, monocyte chemo-attractant protein (MCP)-1 and cytokine-induced neutrophil chemo-attractant (KC), as measured in the peritoneal cavities. Injection of zymosan also induced a time-dependent increase in the production of the anti-inflammatory cytokine interleukin-10 (IL-10) in the peritoneal cavity. When comparing the response between wild-type and iNOS knockout (KO) mice, we observed that the low-level PMN accumulation measured at 1 hr was slightly but significantly increased in the absence of functional iNOS. On the other hand, the delayed response (2-4 hr after zymosan) of PMN accumulation was suppressed in the iNOS KO mice. The early enhancement of PMN infiltration in the iNOS-deficient mice was associated with increased peritoneal levels of MIP-2, KC and IL-10 proteins. The delayed suppression of PMN infiltration was associated with reduced MIP-2 and IL-10 levels in the peritoneal cavity. The lack of iNOS did not affect the release of MIP-1alpha and MCP-1 at any of the time-points studied. The current data demonstrate that iNOS regulates the production of certain CXC (but not CC) proinflammatory chemokines, the production of IL-10 and exerts a biphasic regulatory effect on PMN accumulation in zymosan-induced acute inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.