ArticleProceedings of the National Academy of Sciences of the United States of America1999
Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 66 citations in OpenAlex.
- The role of GATA2 in adult hematopoiesis and cell fate determination.Frontiers in cell and developmental biology · 2023Review
- Towards a New Understanding of Decision-Making by Hematopoietic Stem Cells.International journal of molecular sciences · 2020Review
- The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture.International journal of molecular sciences · 2018Review
- Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.Immunological reviews · 2010Review
- Erythropoietin receptor response circuits.Current opinion in hematology · 2010Review
- Developmental biology: Instructions writ in blood.Nature · 2009Article
- Article
- Cytokine receptors and hematopoietic differentiation.Oncogene · 2007Review
- Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells.Experimental hematology · 2005Article
- The origin of hematopoietic cell type diversity.Oncogene · 2004Review
- Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs.The Journal of experimental medicine · 2004Article
- The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factors.Gene therapy · 2002Review
- Induction of megakaryocytic differentiation in primary human erythroblasts: a physiological basis for leukemic lineage plasticity.The American journal of pathology · 2001Article
- Differentiation commitment and regulator-specific granulocyte-macrophage maturation in a novel pro-B murine leukemic cell line.Leukemia · 2000Article
- Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo.Molecular and cellular biology · 2000Article
- Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells.The Journal of experimental medicine · 1998Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The question of whether extracellular signals influence hematopoiesis by instructing stem cells to commit to a specific hematopoietic lineage (instructive model) or solely by permitting the survival and proliferation of predetermined progenitors (permissive model) has been controversial since the discovery of lineage-dominant hematopoietic cytokines. To study the potential role of cytokines and their receptors in hematopoietic cell fate decisions, we used homologous recombination to replace the thrombopoietin receptor gene (mpl) with a chimeric construct encoding the extracellular domain of mpl and the cytoplasmic domain of the granulocyte colony-stimulating factor receptor (G-CSFR). This chimeric receptor binds thrombopoietin but signals through the G-CSFR intracellular domain. We found that, despite the absence of a functional mpl signaling domain, homozygous knock-in mice had a normal platelet count, indicating that in vivo the cytoplasmic domain of G-CSFR can functionally replace mpl signaling to support normal megakaryopoiesis and platelet formation. This finding is compatible with the permissive model, according to which cytokine receptors provide a nonspecific survival or proliferation signal, and argues against an instructive role of mpl or G-CSFR in hematopoietic cell fate decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.