ArticleProceedings of the National Academy of Sciences of the United States of America1999
Microsporidia are related to Fungi: evidence from the largest subunit of RNA polymerase II and other proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
132 citing papers in PubMed, 524 citations in OpenAlex.
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- Integrative High-Throughput Screening and Microscopic Evidence Implicates Microsporidia as a Potential Pathogen of "Pus Crab" in the Mud Crab (Animals : an open access journal from MDPI · 2025Article
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- Morpho-cultural and molecular characterization of trichoderma species from the northwestern himalayan apple rhizosphere of India.Scientific reports · 2025Article
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- Exploring objective feature sets in constructing the evolution relationship of animal genome sequences.BMC genomics · 2023Article
- The microsporidian polar tube: origin, structure, composition, function, and application.Parasites & vectors · 2023Review
- Widespread infection, diversification and old host associations of Nosema Microsporidia in European freshwater gammarids (Amphipoda).PLoS pathogens · 2023Article
- Intraspecific genetic diversity of the fish-infecting microsporidian parasiteFrontiers in microbiology · 2023Article
- It Took Me a While to Figure out What Science I Really Wanted to Do.Genome biology and evolution · 2022Article
- Microsporidian diversity in the aquatic isopodParasitology · 2022Article
- Phylogenomic Analyses of 2,786 Genes in 158 Lineages Support a Root of the Eukaryotic Tree of Life between Opisthokonts and All Other Lineages.Genome biology and evolution · 2022Article
- A severe microsporidian disease in cultured Atlantic Bluefin Tuna (Thunnus thynnus).IMA fungus · 2022Article
- Full-length transcriptome sequencing and comparative transcriptome analysis ofFrontiers in cellular and infection microbiology · 2022Article
- A Perspective on the Molecular Identification, Classification, and Epidemiology of Enterocytozoon bieneusi of Animals.Experientia supplementum (2012) · 2022Article
- Comparative Genomics of Microsporidia.Experientia supplementum (2012) · 2022Article
- Deciphering Microbial Gene Family Evolution Using Duplication-Transfer-Loss Reconciliation and RANGER-DTL.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Phylogenetic Analysis That Models Compositional Heterogeneity over the Tree.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Chronic Infections in Mammals Due to Microsporidia.Experientia supplementum (2012) · 2022Article
- Fungi Inhabiting the Wheat Endosphere.Pathogens (Basel, Switzerland) · 2021Review
72 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We have determined complete gene sequences encoding the largest subunit of the RNA polymerase II (RBP1) from two Microsporidia, Vairimorpha necatrix and Nosema locustae. Phylogenetic analyses of these and other RPB1 sequences strongly support the notion that Microsporidia are not early-diverging eukaryotes but instead are specifically related to Fungi. Our reexamination of elongation factors EF-1alpha and EF-2 sequence data that had previously been taken as support for an early (Archezoan) divergence of these amitochondriate protists show such support to be weak and likely caused by artifacts in phylogenetic analyses. These EF data sets are, in fact, not inconsistent with a Microsporidia + Fungi relationship. In addition, we show that none of these proteins strongly support a deep divergence of Parabasalia and Metamonada, the other amitochondriate protist groups currently thought to compose early branches. Thus, the phylogenetic placement among eukaryotes for these protist taxa is in need of further critical examination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.