ArticleProceedings of the National Academy of Sciences of the United States of America1999
Persistent membrane association of activated and depalmitoylated G protein alpha subunits.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 87 citations in OpenAlex.
- Rab3gap1 palmitoylation cycling modulates cardiomyocyte exocytosis and atrial natriuretic peptide release.Biophysical journal · 2025Article
- A network of GαScience signaling · 2022Article
- A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy.Molecular biology of the cell · 2021Article
- Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.Communications biology · 2020Article
- Effects of Post-translational Modifications on Membrane Localization and Signaling of Prostanoid GPCR-G Protein Complexes and the Role of Hypoxia.The Journal of membrane biology · 2019Review
- Tubulin, actin and heterotrimeric G proteins: coordination of signaling and structure.Biochimica et biophysica acta · 2014Review
- Regulation of the cardiac sodium pump.Cellular and molecular life sciences : CMLS · 2013Review
- Protein palmitoylation and pathogenesis in apicomplexan parasites.Journal of biomedicine & biotechnology · 2012Review
- The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation.The Journal of biological chemistry · 2011Article
- Subcellular localization of mu-opioid receptor G(s) signaling.The Journal of pharmacology and experimental therapeutics · 2010Article
- Shuttling and translocation of heterotrimeric G proteins and Ras.Trends in pharmacological sciences · 2009Review
- Coupling mode of receptors and G proteins.Naunyn-Schmiedeberg's archives of pharmacology · 2009Review
- Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.Pharmacology & therapeutics · 2007Review
- Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein.The Journal of cell biology · 2005Article
- Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors.The EMBO journal · 2003Article
- Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells.British journal of pharmacology · 2002Article
- Homologous and heterologous uncoupling of muscarinic M(3) and alpha(1B) adrenoceptors to Galpha(q/11) in SH-SY5Y human neuroblastoma cells.British journal of pharmacology · 2001Article
- Regulation of G proteins by covalent modification.Oncogene · 2001Review
- G(q/11) and G(i/o) activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype.British journal of pharmacology · 2001Article
- A proline-rich region and nearby cysteine residues target XLalphas to the Golgi complex region.Molecular biology of the cell · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Heterotrimeric signal-transducing G proteins are organized at the inner surface of the plasma membrane, where they are positioned to interact with membrane-spanning receptors and appropriate effectors. G proteins are activated when they bind GTP and inactivated when they hydrolyze the nucleotide to GDP. However, the topological fate of activated G protein alpha subunits is disputed. One model declares that depalmitoylation of alpha, which accompanies activation by a receptor, promotes release of the protein into the cytoplasm. Our data suggest that activation of G protein alpha subunits causes them to concentrate in subdomains of the plasma membrane but not to be released from the membrane. Furthermore, alpha subunits remained bound to the membrane when they were activated with guanosine 5'-(3-O-thio)triphosphate and depalmitoylated with an acyl protein thioesterase. Limitation of alpha subunits to the plasma membrane obviously restricts their mobility and may contribute to the efficiency and specificity of signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.