ArticleMolecular and cellular biology1999
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 144 citations in OpenAlex.
- MORF4L1 regulation and its role in chromatin remodeling, DNA damage, cellular senescence, and cardiometabolic disease.Vascular pharmacology · 2026Review
- MRG15 alternative splicing regulates CDK1 transcriptional activity in mouse cell senescence and myocardial regeneration.Communications biology · 2025Article
- Phase separation of MRG15 delays cellular senescence.Communications biology · 2025Article
- Evaluating transcriptional alterations associated with ageing and developing age prediction models based on the human blood transcriptome.Biogerontology · 2025Article
- Predicting lung aging using scRNA-Seq data.PLoS computational biology · 2024Article
- Structural and functional insights into the epigenetic regulator MRG15.Acta pharmacologica Sinica · 2024Review
- The Physcomitrella patens chromatin adaptor PpMRG1 interacts with H3K36me3 and regulates light-responsive alternative splicing.Plant physiology · 2021Article
- A male infant with Xq22.2q22.3 duplication containing PLP1 and MID2.Molecular genetics & genomic medicine · 2020Article
- A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass.Aging · 2019Article
- GRM7 polymorphisms and risk of schizophrenia in Iranian population.Metabolic brain disease · 2019Article
- Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants.Protein & cell · 2016Article
- A microdeletion at Xq22.2 implicates a glycine receptor GLRA4 involved in intellectual disability, behavioral problems and craniofacial anomalies.BMC neurology · 2016Article
- Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.PloS one · 2016Article
- Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.Development (Cambridge, England) · 2015Article
- Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression.PLoS genetics · 2014Article
- Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.Bioscience reports · 2013Article
- Alternative splicing of the chromodomain protein Morf4l1 pre-mRNA has implications on cell differentiation in the developing chicken retina.Journal of molecular neuroscience : MN · 2013Article
- Article
- Maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease.International journal of molecular sciences · 2013Article
- Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers.Cancer biology & therapy · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 6 countries.
Funding
Abstract
Based on the dominance of cellular senescence over immortality, immortal human cell lines have been assigned to four complementation groups for indefinite division. Human chromosomes carrying senescence genes have been identified, including chromosome 4. We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence. MORF 4 is a member of a novel family of genes with transcription factor-like motifs. We present here the sequences of the seven family members, their chromosomal locations, and a partial characterization of the three members that are expressed. Elucidation of the mechanism of action of these genes should enhance our understanding of growth regulation and cellular aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.