ArticleMolecular and cellular biology1999
Essential role of the dynamin pleckstrin homology domain in receptor-mediated endocytosis.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 172 citations in OpenAlex.
- The multifaceted significance of phosphoinositides in endocytic trafficking.FEBS letters · 2026Review
- Endoplasmic reticulum patterns insect cuticle nanostructure.The Journal of cell biology · 2026Article
- Membranes are functionalized by a proteolipid code.BMC biology · 2024Article
- Cellular and structural insight into dynamin function during endocytic vesicle formation: a tale of 50 years of investigation.Bioscience reports · 2022Review
- PI(4,5)P2: signaling the plasma membrane.The Biochemical journal · 2022Article
- Impact of CaBiomolecules · 2022Article
- Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.Autophagy · 2021Article
- Flexible pivoting of dynamin pleckstrin homology domain catalyzes fission: insights into molecular degrees of freedom.Molecular biology of the cell · 2021Article
- Article
- Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease.Frontiers in cellular neuroscience · 2021Article
- Structural Insights into the Mechanism of Dynamin Superfamily Proteins.Trends in cell biology · 2019Review
- Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture.The Journal of cell biology · 2018Article
- Tied up: Does altering phosphoinositide-mediated membrane trafficking influence neurodegenerative disease phenotypes?Journal of genetics · 2018Review
- Mutations in the PH Domain of DNM1 are associated with a nonepileptic phenotype characterized by developmental delay and neurobehavioral abnormalities.Molecular genetics & genomic medicine · 2018Article
- CaThe Journal of biological chemistry · 2017Article
- Real-time imaging of sodium glucose transporter (SGLT1) trafficking and activity in single cells.Physiological reports · 2017Article
- The pleckstrin-homology domain of dynamin is dispensable for membrane constriction and fission.Molecular biology of the cell · 2017Article
- Insights into dynamin-associated disorders through analysis of equivalent mutations in the yeast dynamin Vps1.Microbial cell (Graz, Austria) · 2016Article
- Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.Biochimica et biophysica acta · 2015Article
- Epileptic encephalopathy-causing mutations in DNM1 impair synaptic vesicle endocytosis.Neurology. Genetics · 2015Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pleckstrin homology (PH) domains are found in numerous membrane-associated proteins and have been implicated in the mediation of protein-protein and protein-phospholipid interactions. Dynamin, a GTPase required for clathrin-dependent endocytosis, contains a PH domain which binds to phosphoinositides and participates in the interaction between dynamin and the betagamma subunits of heterotrimeric G proteins. The PH domain is essential for expression of phosphoinositide-stimulated GTPase activity of dynamin in vitro, but its involvement in the endocytic process is unknown. We expressed a series of dynamin PH domain mutants in cultured cells and determined their effect on transferrin uptake by those cells. Endocytosis is blocked in cells expressing a PH domain deletion mutant and a point mutant that fails to interact with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. In contrast, expression of a point mutant with unimpaired PI(4,5)P2 interaction has no effect on transferrin uptake. These results demonstrate the significance of the PH domain for dynamin function and suggest that its role may be to mediate interactions between dynamin and phosphoinositides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.